%0 Journal Article
%T Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis.
%A Cai Q
%A Shubhra QTH
%J Trends Immunol
%V 45
%N 2
%D 2024 02 18
%M 38242759
%F 19.709
%R 10.1016/j.it.2024.01.001
%X In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this inflammatory cell death mechanism.