{Reference Type}: Journal Article
{Title}: Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis.
{Author}: Cai Q;Shubhra QTH;
{Journal}: Trends Immunol
{Volume}: 45
{Issue}: 2
{Year}: 2024 02 18
{Factor}: 19.709
{DOI}: 10.1016/j.it.2024.01.001
{Abstract}: In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this inflammatory cell death mechanism.