PDF(Pubmed)
Abstract：
Our representative studies to achieve sustainable use of crude drugs and ensure their stable quality are introduced: comprehensive studies on genetic, chemical, and sometimes pharmacological diversity of Asian medicinal plants including Paeonia lactiflora, Glycyrrhiza uralensis, Ephedra spp., Saposhnikovia divaricata, and Curcuma spp., as well as their related crude drugs. (1) For peony root, after genetic and chemical diversity analysis of crude drug samples including white and red peony root in China, the value-added resources with quality similar to red peony root were explored among 61 horticultural P. lactiflora varieties, and two varieties were identified. In addition, an optimized post-harvest processing method, which resulted in high contents of the main active components in the produced root, was developed to promote cultivation and production of brand peony root. (2) Alternative resources of glycyrrhiza, ephedra herb and saposhnikovia root and rhizome of Japanese Pharmacopoeia grade were discovered in eastern Mongolia after field investigation and quality assessment comparing Mongolian plants with Chinese crude drugs. Simultaneously, suitable specimens and prospective regions for cultivation were proposed. (3) Because of the wide distribution and morphological similarities of Curcuma species, classification of some species is debated, which leads to confusion in the use of Curcuma crude drugs. Molecular analyses of the intron length polymorphism (ILP) markers in genes encoding diketide-CoA synthase (DCS) and curcumin synthase (CURS) and trnK sequences, combined with essential oils analysis, were demonstrated as useful for standardization of Curcuma crude drugs. The above studies, representing various facets, can be applied to other crude drugs.
摘要：
我们为实现原料药的可持续使用并确保其质量稳定而进行的代表性研究介绍了:对遗传的综合研究,化学,有时亚洲药用植物的药理多样性，包括芍药，甘草，麻黄属物种。,麻风,和姜黄属。,以及他们的相关原料药。(1)对于牡丹根，经过对中国白芍和赤芍等生药样品的遗传和化学多样性分析，在61个园艺百草品种中探索了质量与赤芍相似的增值资源，并鉴定了两个品种。此外,一种优化的收获后处理方法，这导致了生产的根中主要活性成分的高含量，旨在促进牡丹品牌的种植和生产。(2)甘草替代资源,经过实地调查和质量评估，将蒙古植物与中国原料药进行了比较，在蒙古东部发现了日本药典级的麻黄草根和防风根茎。同时,提出了合适的标本和预期的栽培区域。(3)由于姜黄属物种分布广泛、形态相似,一些物种的分类存在争议，这导致姜黄原料药的使用混乱。编码二酮-CoA合酶（DCS）和姜黄素合酶（CRAS）和trnK序列的基因中内含子长度多态性（ILP）标记的分子分析，结合精油分析，被证明可用于姜黄原料药的标准化。上述研究,代表各个方面，可用于其他生药。
