背景:芍药科仅含有芍药属,被认为是开花植物的主要群体。已经描述了芍药科草药的几种传统和药理应用。本文旨在通过对芍药属药材的潜在作用机制和信号通路的研究,确定芍药属中最流行的药材的药理活性,为进一步深入研究芍药药材资源提供思路。
方法:从1995年1月1日至2024年5月15日,通过PubMed和Scopus数据库搜索了“芍药科”关键字。只有与药理学有关的论文,药剂学,并提取了毒理学。随后讨论了Paeonia植物的作用机制和信号通路的潜在药理活性。
结果:在我们的冒险之后,只有15种芍药草药的药理学应用得到了充分评估。白芍。,PaeoniasuffruticosaAndrews,PaeoniaemodiRoyle是最普遍的Paeonia植物之一,在现代药理学研究中引起了越来越多的关注。芍药草药具有各种药理应用,如抗炎,抗过敏,抗癌,抗菌,心血管保护,化妆品和护肤,自由基清除,保肝和抗溃疡,抗糖尿病,肌肉骨骼,和神经保护作用,并且可以在关键的医疗条件下用作替代疗法。
结论:在芍药的应用中,抗炎和抗氧化活性至关重要,因为大多数其他药理作用都归因于它们。换句话说,核因子(NF)-κB和核因子类2相关因子2(Nrf2)可被认为是参与芍药药理活性的最重要的信号通路。
BACKGROUND: The Paeoniaceae family contains only the
Paeonia genus and is considered the major group of flowering plants. Several traditional and pharmacological applications of Paeoniaceae herbs have been described. The current paper aimed to determine the pharmacological activities of the most prevalent herbs from the genus
Paeonia by focusing on the underlying mechanism of action and signaling pathways to provide insight for further in-depth research on the medicinal resources of Paeonia.
METHODS: The \"Paeoniaceae\" keyword was searched from 1st January 1995 to 15th May 2024 through the PubMed and Scopus databases. Only papers related to pharmacology, pharmaceutics, and toxicology were extracted. The possible pharmacological activity of the
Paeonia plants underlying their mechanism of action and signaling pathways was subsequently discussed.
RESULTS: Following our venture, only 15
Paeonia herbs were adequately evaluated for their pharmacological applications.
Paeonia lactiflora Pall.,
Paeonia suffruticosa Andrews, and
Paeonia emodi Royle are among the most prevalent Paeonia plants that have attracted increased amounts of attention in modern pharmacological studies. Paeonia herbs possess various pharmacological applications, such as anti-inflammatory, anti-allergic, anticancer, antimicrobial, cardiovascular protective, cosmetic and skincare, radical scavenging, hepatoprotective and anti-ulcerative, anti-diabetic, musculoskeletal, and neuroprotective effects, and can be used as alternative therapies under critical medical conditions.
CONCLUSIONS: Among the applications of Paeonia herbs, anti-inflammatory and antioxidant activities are critical, as most of the other pharmacological effects are attributed to them. In other words, nuclear factor (NF)-κB and nuclear factor erythroid 2-related factor 2 (Nrf2) can be considered the most important signaling pathways involved in the pharmacological activity of Paeonia herbs.