PDF(Pubmed)
Abstract：
Vitamin K (VK), a fat-soluble vitamin, is essential for the clotting of blood because of its role in the production of clotting factors in the liver. Moreover, researchers continue to explore the role of VK as an emerging novel bioactive molecule with the potential function of improving bone health. This review focuses on the effects of VK on bone health and related mechanisms, covering VK research history, homologous analogs, dietary sources, bioavailability, recommended intake, and deficiency. The information summarized here could contribute to the basic and clinical research on VK as a natural dietary additive and drug candidate for bone health. Future research is needed to extend the dietary VK database and explore the pharmacological safety of VK and factors affecting VK bioavailability to provide more support for the bone health benefits of VK through more clinical trials.
摘要：
维生素K（VK），一种脂溶性维生素,对血液的凝固至关重要，因为它在肝脏中凝血因子的产生中发挥作用。此外，研究人员继续探索VK作为一种新兴的具有改善骨骼健康潜在功能的新型生物活性分子的作用.本文就VK对骨骼健康的影响及相关机制进行综述。涵盖VK研究历史，同源类似物，膳食来源，生物利用度，推荐摄入量,和不足。此处总结的信息可能有助于VK作为天然饮食添加剂和骨骼健康候选药物的基础和临床研究。未来的研究需要扩展饮食VK数据库，并探索VK的药理安全性和影响VK生物利用度的因素，以通过更多的临床试验为VK的骨骼健康益处提供更多支持。
