Abstract：
BACKGROUND: Mild Cognitive Impairment (MCI) is common in Parkinson\'s Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients\' subjective cognitive and communicative difficulties has not been explored.
OBJECTIVE: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints.
METHODS: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson\'s Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted.
RESULTS: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores.
CONCLUSIONS: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD.
OBJECTIVE: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints.
METHODS: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson\'s Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted.
RESULTS: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores.
CONCLUSIONS: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD.
摘要：
背景：轻度认知损害（MCI）在帕金森病（PD）中很常见。很少有研究比较有和没有由于PD（PD-MCI）导致的MCI患者的健康相关生活质量（HRQoL），其与患者主观认知和沟通困难的相关性尚未得到探讨。
目的：我们旨在比较PD-MCI和不含MCI的PD（PD-nMCI）的HRQoL，并探讨其与主观认知和交际抱怨的可能关系。
方法：我们纳入了29例PD-nMCI和11例PD-MCI患者。用帕金森病问卷-39(PDQ-39)评估HRQoL:其认知维度被用作主观认知投诉的量度,其主观交际抱怨的交际维度，和汇总指数(PDQ-39SI)作为HRQoL的指标。认知维度和沟通维度之间的非参数偏相关，并进行了调整后的PDQ-39SI。
结果：与PD-nMCI患者相比，PD-MCI患者的主观认知和交流主诉更大，HRQoL更差。在PD-MCI组,主观认知和交际主诉均与调整后的HRQoL评分具有显著的直接相关性.
结论：HRQoL似乎在PD-MCI中受到影响，并且可能受到更大的主观认知和交流抱怨的影响。包括患者报告的HRQoL结果测量，提供认知和言语康复，以及应对这些缺陷的心理治疗策略可以增强PD以患者为中心的方法。
目的：我们旨在比较PD-MCI和不含MCI的PD（PD-nMCI）的HRQoL，并探讨其与主观认知和交际抱怨的可能关系。
方法：我们纳入了29例PD-nMCI和11例PD-MCI患者。用帕金森病问卷-39(PDQ-39)评估HRQoL:其认知维度被用作主观认知投诉的量度,其主观交际抱怨的交际维度，和汇总指数(PDQ-39SI)作为HRQoL的指标。认知维度和沟通维度之间的非参数偏相关，并进行了调整后的PDQ-39SI。
结果：与PD-nMCI患者相比，PD-MCI患者的主观认知和交流主诉更大，HRQoL更差。在PD-MCI组,主观认知和交际主诉均与调整后的HRQoL评分具有显著的直接相关性.
结论：HRQoL似乎在PD-MCI中受到影响，并且可能受到更大的主观认知和交流抱怨的影响。包括患者报告的HRQoL结果测量，提供认知和言语康复，以及应对这些缺陷的心理治疗策略可以增强PD以患者为中心的方法。
