OBJECTIVE: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints.
METHODS: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson\'s Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted.
RESULTS: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores.
CONCLUSIONS: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD.
目的:我们旨在比较PD-MCI和不含MCI的PD(PD-nMCI)的HRQoL,并探讨其与主观认知和交际抱怨的可能关系。
方法:我们纳入了29例PD-nMCI和11例PD-MCI患者。用帕金森病问卷-39(PDQ-39)评估HRQoL:其认知维度被用作主观认知投诉的量度,其主观交际抱怨的交际维度,和汇总指数(PDQ-39SI)作为HRQoL的指标。认知维度和沟通维度之间的非参数偏相关,并进行了调整后的PDQ-39SI。
结果:与PD-nMCI患者相比,PD-MCI患者的主观认知和交流主诉更大,HRQoL更差。在PD-MCI组,主观认知和交际主诉均与调整后的HRQoL评分具有显著的直接相关性.
结论:HRQoL似乎在PD-MCI中受到影响,并且可能受到更大的主观认知和交流抱怨的影响。包括患者报告的HRQoL结果测量,提供认知和言语康复,以及应对这些缺陷的心理治疗策略可以增强PD以患者为中心的方法。