炎症损伤的可逆表观遗传记忆控制小鼠胰腺的谱系可塑性和肿瘤起始。
关键词: ATAC-seq CUT&TAG cell fate epigenetic memory inflammatory injury lineage plasticity pancreatic cancer pancreatitis single-cell RNA sequencing tumorigenesis
Mesh : Mice Animals Pancreatic Neoplasms / genetics pathology Epigenetic Memory Cell Transformation, Neoplastic / pathology Acinar Cells / pathology Pancreas / pathology Chromatin / genetics Metaplasia / pathology Carcinoma, Pancreatic Ductal / genetics
来 源:
DOI:10.1016/j.devcel.2023.11.008
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