Abstract：
Dental restorations are in increasing demand, yet their success rate strongly decreases after 5-10 years post-implantation, attributed in part to mismatching properties with the surrounding buccal environment that causes failures and wear. Among current research to address this issue, biomimetic approaches are promising. Nacre-like ceramic composites are particularly interesting because they combine multiple antagonistic properties making them more resistant to failure in harsh environment than other materials. With the rapid progress in 3D printing producing nacre-like structures has open up new opportunities not yet realised. In this paper, nacre-like composites of various compositions are reviewed in the context of hypothetical biomimetic dental restorations. Their structural, functional and biological properties are compared with those of dentin, enamel, and bone to determine which composition would be the most suitable for each of the 3 mineralized regions found in teeth. The role of complex microstructures and mineral orientations are discussed as well as 3D printing methods that allow the design and fabrication of such complex architectures. Finally, usage of these processes and anticipated prospects for next generation biomimetic dental replacements are discussed to suggest future research directions in this area. STATEMENT OF SIGNIFICANCE: With the current ageing population, dental health is a major issue and current dental restorations still have shortcomings. For the next generation of dental restorations, more biomimetic approaches would be desirable to increase their durability. Among current materials, nacre-like ceramic composites are interesting because they can approach the various structural properties found in the different parts of our teeth. Furthermore, it is also possible to embed self-sensing functionalities to enable monitoring of oral health. Finally, new recent 3D printing technologies now permit the fabrication of complex shapes with local compositions and local microstructures. With this current status of the research, we anticipate new dental restorations designs and highlight the remaining gaps and issues to address.
摘要：
牙科修复的需求不断增加，然而，他们的成功率在植入后5-10年后急剧下降，部分归因于与周围口腔环境的不匹配特性，导致故障和磨损。在目前解决这一问题的研究中，仿生方法很有前途。类似珍珠层的陶瓷复合材料特别有趣，因为它们结合了多种拮抗特性，使其比其他材料更能抵抗恶劣环境中的破坏。随着3D打印技术的快速发展，生产类似珍珠层的结构开辟了尚未实现的新机会。在本文中,在假设的仿生牙科修复体的背景下，对各种成分的类珍珠层复合材料进行了综述。他们的结构，将功能和生物学特性与牙本质进行比较，搪瓷,和骨骼，以确定哪种成分最适合牙齿中发现的3个矿化区域中的每一个。讨论了复杂微观结构和矿物取向的作用，以及允许设计和制造这种复杂结构的3D打印方法。最后,讨论了这些过程的使用以及下一代仿生牙齿替代品的预期前景，以建议该领域的未来研究方向。重要性声明：随着当前人口老龄化，牙齿健康是一个主要问题，目前的牙齿修复仍然存在缺陷。对于下一代牙科修复，更多的仿生方法将是可取的，以增加其耐久性。在目前的材料中，类似珍珠层的陶瓷复合材料很有趣，因为它们可以接近我们牙齿不同部位的各种结构特性。此外，还可以嵌入自感功能以实现口腔健康的监测。最后,新的3D打印技术现在允许制造具有局部成分和局部微结构的复杂形状。结合目前的研究现状,我们期待新的牙科修复设计，并强调剩余的差距和需要解决的问题。
