Abstract：
Preventing the progression of gastric precancerous lesions (GPLs) can reduce the morbidity and mortality of gastric cancer (GC). The preventive effect of a plant-based diet on cancers has been widely recognised. In this case-control study, 1,130 subjects were included using 1:1 propensity score matching for age and sex. Dietary habits, anthropometry and sample collection were conducted using standard and effective methods. Plant-based diet indices (PDIs) were calculated using a previously reported method. Faecal samples were analysed by untargeted metabolomics. Our study found that adherence to a healthy plant-based diet was inversely associated with the occurrence of GPLs. Metabolomic analysis identified six different metabolites correlated with GPLs, among which luteolin-related metabolites may be used as biomarkers of the association between PDIs and GPLs. In addition, the difference in N-acyl amides found in PDIs needs further verification. Our findings suggest that a healthy plant-based diet may have a protective effect against GPLs.
摘要：
预防胃癌前病变（GPL）的进展可以降低胃癌（GC）的发病率和死亡率。植物性饮食对癌症的预防作用已被广泛认可。在这项病例对照研究中，纳入1,130名受试者，使用年龄和性别匹配的1:1倾向评分。饮食习惯,使用标准和有效的方法进行人体测量和样本收集。使用先前报道的方法计算基于植物的饮食指数(PDI)。通过非靶向代谢组学分析粪便样品。我们的研究发现，坚持健康的植物性饮食与GPL的发生成反比。代谢组学分析确定了与GPL相关的六种不同的代谢物，其中木犀草素相关代谢物可用作PDIs和GPL之间关联的生物标志物。此外,PDIs中N-酰基酰胺的差异需要进一步验证。我们的发现表明，健康的植物性饮食可能对GPL具有保护作用。
