%0 Journal Article
%T Healthy plant-based diet might be inversely associated with gastric precancerous lesions: new evidence from a case-control study based on dietary pattern and fecal metabolic profiling.
%A Cheng W
%A Lin X
%A Wang T
%A Zhang X
%A Xu F
%A Wang L
%A Wang M
%A Zhang M
%A Xia T
%A Zhang D
%A Qian S
%A Yang W
%A Hu A
%A Tang M
%A Hu X
%A Wang Y
%A Zhao Q
%J Int J Food Sci Nutr
%V 75
%N 1
%D 2024 Feb 8
%M 37941094
%F 4.444
%R 10.1080/09637486.2023.2279916
%X Preventing the progression of gastric precancerous lesions (GPLs) can reduce the morbidity and mortality of gastric cancer (GC). The preventive effect of a plant-based diet on cancers has been widely recognised. In this case-control study, 1,130 subjects were included using 1:1 propensity score matching for age and sex. Dietary habits, anthropometry and sample collection were conducted using standard and effective methods. Plant-based diet indices (PDIs) were calculated using a previously reported method. Faecal samples were analysed by untargeted metabolomics. Our study found that adherence to a healthy plant-based diet was inversely associated with the occurrence of GPLs. Metabolomic analysis identified six different metabolites correlated with GPLs, among which luteolin-related metabolites may be used as biomarkers of the association between PDIs and GPLs. In addition, the difference in N-acyl amides found in PDIs needs further verification. Our findings suggest that a healthy plant-based diet may have a protective effect against GPLs.