{Reference Type}: Journal Article
{Title}: Healthy plant-based diet might be inversely associated with gastric precancerous lesions: new evidence from a case-control study based on dietary pattern and fecal metabolic profiling.
{Author}: Cheng W;Lin X;Wang T;Zhang X;Xu F;Wang L;Wang M;Zhang M;Xia T;Zhang D;Qian S;Yang W;Hu A;Tang M;Hu X;Wang Y;Zhao Q;
{Journal}: Int J Food Sci Nutr
{Volume}: 75
{Issue}: 1
{Year}: 2024 Feb 8
{Factor}: 4.444
{DOI}: 10.1080/09637486.2023.2279916
{Abstract}: Preventing the progression of gastric precancerous lesions (GPLs) can reduce the morbidity and mortality of gastric cancer (GC). The preventive effect of a plant-based diet on cancers has been widely recognised. In this case-control study, 1,130 subjects were included using 1:1 propensity score matching for age and sex. Dietary habits, anthropometry and sample collection were conducted using standard and effective methods. Plant-based diet indices (PDIs) were calculated using a previously reported method. Faecal samples were analysed by untargeted metabolomics. Our study found that adherence to a healthy plant-based diet was inversely associated with the occurrence of GPLs. Metabolomic analysis identified six different metabolites correlated with GPLs, among which luteolin-related metabolites may be used as biomarkers of the association between PDIs and GPLs. In addition, the difference in N-acyl amides found in PDIs needs further verification. Our findings suggest that a healthy plant-based diet may have a protective effect against GPLs.