Abstract：
OBJECTIVE: We aimed to explore the clinical characteristics of Campylobacter bacteraemia and identify the trends, risk factors for mortality, and antimicrobial susceptibility patterns from clinical samples.
METHODS: This retrospective cohort study included patients confirmed to have Campylobacter bacteraemia from seven hospitals between January 2010 and June 2021. Data on demographics and underlying history, clinical manifestation, and antimicrobial susceptibility patterns were collected and analyzed. Annual cases of Campylobacter enteritis were extracted from a public database.
RESULTS: A total of 108 patients were included, and five species were isolated. Campylobacter jejuni accounted for 54 (50.0%) cases and 17 (16%) patients had no symptoms other than fever. In-hospital mortality occurred in 14 (13.0%) patients. C. jejuni bacteraemia was associated with lower mortality compared to non-C. jejuni bacteraemia. Underlying cancer and septic shock were the significant factors associated with in-hospital mortality. Quinolone resistance was high (59%), whereas only 4% of isolates exhibited macrolide resistance. There has been a significant increase in the number of Campylobacter enteritis cases, which was strongly correlated with the number of Campylobacter bacteraemia cases (Pearson\'s coefficient: 0.953; p < 0.0001).
CONCLUSIONS: The notably increasing incidence of Campylobacter bacteraemia and antibiotic resistance patterns can challenge the treatment, necessitating collective efforts of national surveillance and networks by many departments.
METHODS: This retrospective cohort study included patients confirmed to have Campylobacter bacteraemia from seven hospitals between January 2010 and June 2021. Data on demographics and underlying history, clinical manifestation, and antimicrobial susceptibility patterns were collected and analyzed. Annual cases of Campylobacter enteritis were extracted from a public database.
RESULTS: A total of 108 patients were included, and five species were isolated. Campylobacter jejuni accounted for 54 (50.0%) cases and 17 (16%) patients had no symptoms other than fever. In-hospital mortality occurred in 14 (13.0%) patients. C. jejuni bacteraemia was associated with lower mortality compared to non-C. jejuni bacteraemia. Underlying cancer and septic shock were the significant factors associated with in-hospital mortality. Quinolone resistance was high (59%), whereas only 4% of isolates exhibited macrolide resistance. There has been a significant increase in the number of Campylobacter enteritis cases, which was strongly correlated with the number of Campylobacter bacteraemia cases (Pearson\'s coefficient: 0.953; p < 0.0001).
CONCLUSIONS: The notably increasing incidence of Campylobacter bacteraemia and antibiotic resistance patterns can challenge the treatment, necessitating collective efforts of national surveillance and networks by many departments.
摘要：
目的：我们旨在探讨弯曲菌菌血症的临床特点和趋势，死亡的危险因素，和来自临床样本的抗菌药物敏感性模式。
方法：这项回顾性队列研究纳入了2010年1月至2021年6月7家医院证实患有弯曲杆菌菌血症的患者。人口统计数据和基本历史，临床表现,收集和分析抗菌药物敏感性模式。从公共数据库中提取弯曲杆菌肠炎的年度病例。
结果：共纳入108例患者，5个物种被隔离。空肠弯曲菌占54例（50.0％），17例（16％）患者除发烧外没有其他症状。14例（13.0%）患者发生院内死亡。与非空肠杆菌菌血症相比，空肠杆菌菌血症的死亡率较低。空肠菌血症.基础癌症和感染性休克是与住院死亡率相关的重要因素。喹诺酮耐药率很高（59%），而只有4%的分离株表现出大环内酯耐药性。弯曲杆菌肠炎的病例有显著增加,这与弯曲杆菌菌血症病例数密切相关（皮尔逊系数：0.953；p<0.0001）。
结论：弯曲杆菌菌血症和抗生素耐药模式的发病率显著增加可能对治疗提出挑战，许多部门需要国家监测和网络的集体努力。
方法：这项回顾性队列研究纳入了2010年1月至2021年6月7家医院证实患有弯曲杆菌菌血症的患者。人口统计数据和基本历史，临床表现,收集和分析抗菌药物敏感性模式。从公共数据库中提取弯曲杆菌肠炎的年度病例。
结果：共纳入108例患者，5个物种被隔离。空肠弯曲菌占54例（50.0％），17例（16％）患者除发烧外没有其他症状。14例（13.0%）患者发生院内死亡。与非空肠杆菌菌血症相比，空肠杆菌菌血症的死亡率较低。空肠菌血症.基础癌症和感染性休克是与住院死亡率相关的重要因素。喹诺酮耐药率很高（59%），而只有4%的分离株表现出大环内酯耐药性。弯曲杆菌肠炎的病例有显著增加,这与弯曲杆菌菌血症病例数密切相关（皮尔逊系数：0.953；p<0.0001）。
结论：弯曲杆菌菌血症和抗生素耐药模式的发病率显著增加可能对治疗提出挑战，许多部门需要国家监测和网络的集体努力。
