METHODS: An electronic search of the literature was conducted using PubMed, Embase and Web of science databases to identify studies related to TBS and T1D, supplemented by an additional manual check of the reference list of relevant original and review articles. All data was analyzed using a random effects model. Results were compared using standardized mean differences (SMD) and 95% confidence intervals (CI). P ≤ 0.05 was considered statistically significant. Review Manager 5.4 software and Stata 17.0 software were used for statistical analysis.
RESULTS: Seven cross-sectional studies involving 848 participants were included. TBS was lower in T1D patients than in healthy controls on random effects analysis, with no heterogeneity (SMD = - 0.39, 95% CI [- 0.53, - 0.24], P < 0.001; I2 = 0%). In addition, by subgroup analysis, T1D patients were strongly associated with reduced TBS in different regions and age groups, and the results were independent of covariate adjustment.
CONCLUSIONS: This study showed that TBS was lower in patients with T1D than in healthy individuals with normal blood glucose levels, suggesting that TBS may be a useful measure to assess fracture risk in T1D.
方法:使用PubMed对文献进行电子搜索,Embase和Webofscience数据库,以确定与TBS和T1D相关的研究,辅以额外的手动检查相关原始和评论文章的参考列表。使用随机效应模型分析所有数据。使用标准化平均差异(SMD)和95%置信区间(CI)比较结果。P≤0.05被认为具有统计学意义。采用ReviewManager5.4软件和Stata17.0软件进行统计分析。
结果:纳入了7项横断面研究,涉及848名参与者。根据随机效应分析,T1D患者的TBS低于健康对照组,无异质性(SMD=-0.39,95%CI[-0.53,-0.24],P<0.001;I2=0%)。此外,通过亚组分析,T1D患者在不同地区和年龄组与TBS降低密切相关。结果与协变量调整无关。
结论:这项研究表明,T1D患者的TBS低于血糖水平正常的健康个体,提示TBS可能是评估T1D骨折风险的有用指标。