PDF(Pubmed)
Abstract：
BACKGROUND: Bone fragility is a recognized complication of type 1 diabetes (T1D). Thus, lower trabecular bone score (TBS) measurements in T1D patients can be predicted. However, the results of current studies on TBS in patients with T1D are inconsistent. In this context, the present study aimed to test the hypothesis that T1D is associated with lower TBS through a meta-analysis.
METHODS: An electronic search of the literature was conducted using PubMed, Embase and Web of science databases to identify studies related to TBS and T1D, supplemented by an additional manual check of the reference list of relevant original and review articles. All data was analyzed using a random effects model. Results were compared using standardized mean differences (SMD) and 95% confidence intervals (CI). P ≤ 0.05 was considered statistically significant. Review Manager 5.4 software and Stata 17.0 software were used for statistical analysis.
RESULTS: Seven cross-sectional studies involving 848 participants were included. TBS was lower in T1D patients than in healthy controls on random effects analysis, with no heterogeneity (SMD = - 0.39, 95% CI [- 0.53, - 0.24], P < 0.001; I2 = 0%). In addition, by subgroup analysis, T1D patients were strongly associated with reduced TBS in different regions and age groups, and the results were independent of covariate adjustment.
CONCLUSIONS: This study showed that TBS was lower in patients with T1D than in healthy individuals with normal blood glucose levels, suggesting that TBS may be a useful measure to assess fracture risk in T1D.
METHODS: An electronic search of the literature was conducted using PubMed, Embase and Web of science databases to identify studies related to TBS and T1D, supplemented by an additional manual check of the reference list of relevant original and review articles. All data was analyzed using a random effects model. Results were compared using standardized mean differences (SMD) and 95% confidence intervals (CI). P ≤ 0.05 was considered statistically significant. Review Manager 5.4 software and Stata 17.0 software were used for statistical analysis.
RESULTS: Seven cross-sectional studies involving 848 participants were included. TBS was lower in T1D patients than in healthy controls on random effects analysis, with no heterogeneity (SMD = - 0.39, 95% CI [- 0.53, - 0.24], P < 0.001; I2 = 0%). In addition, by subgroup analysis, T1D patients were strongly associated with reduced TBS in different regions and age groups, and the results were independent of covariate adjustment.
CONCLUSIONS: This study showed that TBS was lower in patients with T1D than in healthy individuals with normal blood glucose levels, suggesting that TBS may be a useful measure to assess fracture risk in T1D.
摘要：
背景：骨脆性是公认的1型糖尿病（T1D）的并发症。因此，可以预测T1D患者骨小梁评分（TBS）的测量值。然而,目前对T1D患者的TBS研究结果不一致.在这种情况下，本研究旨在通过荟萃分析检验T1D与较低TBS相关的假设.
方法：使用PubMed对文献进行电子搜索，Embase和Webofscience数据库，以确定与TBS和T1D相关的研究，辅以额外的手动检查相关原始和评论文章的参考列表。使用随机效应模型分析所有数据。使用标准化平均差异（SMD）和95％置信区间（CI）比较结果。P≤0.05被认为具有统计学意义。采用ReviewManager5.4软件和Stata17.0软件进行统计分析。
结果：纳入了7项横断面研究，涉及848名参与者。根据随机效应分析，T1D患者的TBS低于健康对照组，无异质性(SMD=-0.39，95%CI[-0.53，-0.24]，P<0.001；I2=0%）。此外,通过亚组分析，T1D患者在不同地区和年龄组与TBS降低密切相关。结果与协变量调整无关。
结论：这项研究表明，T1D患者的TBS低于血糖水平正常的健康个体，提示TBS可能是评估T1D骨折风险的有用指标。
方法：使用PubMed对文献进行电子搜索，Embase和Webofscience数据库，以确定与TBS和T1D相关的研究，辅以额外的手动检查相关原始和评论文章的参考列表。使用随机效应模型分析所有数据。使用标准化平均差异（SMD）和95％置信区间（CI）比较结果。P≤0.05被认为具有统计学意义。采用ReviewManager5.4软件和Stata17.0软件进行统计分析。
结果：纳入了7项横断面研究，涉及848名参与者。根据随机效应分析，T1D患者的TBS低于健康对照组，无异质性(SMD=-0.39，95%CI[-0.53，-0.24]，P<0.001；I2=0%）。此外,通过亚组分析，T1D患者在不同地区和年龄组与TBS降低密切相关。结果与协变量调整无关。
结论：这项研究表明，T1D患者的TBS低于血糖水平正常的健康个体，提示TBS可能是评估T1D骨折风险的有用指标。
