METHODS: Sixty-three patients with acute anterior circulation ischemic stroke from 2017 to 2022 who underwent STAGE, diffusion weighted imaging (DWI) and dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) within 7 days were retrospectively enrolled. The areas with reduced diffusion and hypo-perfusion were segmented based on apparent diffusion coefficient (ADC) value < 0.62 × 10-3mm2/s and time-to-maximum (Tmax) thresholds (4, 6, 8, and 10 seconds). We measured the T1 value in the diffusion reduced and every 2 s Tmax strata regions and calculated rT1 (T1ipsi/T1contra) to explore the relationship between rT1 value, Tmax, and onset time.
RESULTS: rT1 value was increased in diffusion reduced (1.42) and hypo-perfused regions (1.02, 1.06, 1.12, 1.27, Tmax 4-6 s, 6-8 s, 8-10 s, > 10 s, respectively; all different from 1, P < 0.001). rT1 value was positively correlated with Tmax (rs = 0.61, P < 0.001) and onset time in area with reduced diffusion (rs = 0.39, P = 0.014).
CONCLUSIONS: Increased rT1 value in different hypo-perfused brain regions using T1 mapping derived by STAGE may reflect the edema; it was associated with the severity of Tmax and showed a weak correlation with the onset time in diffusion reduced areas.
方法:2017-2022年63例急性前循环缺血性脑卒中患者,回顾性纳入7天内的弥散加权成像(DWI)和动态磁敏感对比灌注加权成像(DSC-PWI).根据表观扩散系数(ADC)值<0.62×10-3mm2/s和最大时间(Tmax)阈值(4、6、8和10秒)对扩散减少和灌注不足的区域进行分割。我们测量了扩散减少和每2sTmax地层区域的T1值,并计算了rT1(T1ipsi/T1contra)来探索rT1值之间的关系,Tmax,和发病时间。
结果:rT1值在扩散减少(1.42)和低灌注区域(1.02、1.06、1.12、1.27,Tmax4-6s,6-8秒,8-10s,>10s,分别为;均不同于1,P<0.001)。rT1值与Tmax(rs=0.61,P<0.001)和扩散减少区域的起效时间(rs=0.39,P=0.014)呈正相关。
结论:使用由STAGE得出的T1作图,不同低灌注脑区的rT1值增加可能反映了水肿;它与Tmax的严重程度相关,并且与扩散减少区域的起效时间相关性弱。