{Reference Type}: Observational Study
{Title}: Impaired T1 mapping and Tmax during the first 7 days after ischemic stroke. A retrospective observational study.
{Author}: Shen L;Lu X;Wang H;Wu G;Guo Y;Zheng S;Ren L;Zhang H;Huang L;Ren B;Zhu J;Xia S;
{Journal}: J Stroke Cerebrovasc Dis
{Volume}: 32
{Issue}: 12
{Year}: 2023 Dec 14
{Factor}: 2.677
{DOI}: 10.1016/j.jstrokecerebrovasdis.2023.107383
{Abstract}: <B>OBJECTIVE: </B>To measure the relative T1 (rT1) value in different hypo-perfused regions after ischemic stroke using T1 mapping derived by Strategically Acquired Gradient Echo (STAGE) and assess its relationship with onset time and severity of ischemia.<BR><B>METHODS: </B>Sixty-three patients with acute anterior circulation ischemic stroke from 2017 to 2022 who underwent STAGE, diffusion weighted imaging (DWI) and dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) within 7 days were retrospectively enrolled. The areas with reduced diffusion and hypo-perfusion were segmented based on apparent diffusion coefficient (ADC) value < 0.62 × 10-3mm2/s and time-to-maximum (Tmax) thresholds (4, 6, 8, and 10 seconds). We measured the T1 value in the diffusion reduced and every 2 s Tmax strata regions and calculated rT1 (T1ipsi/T1contra) to explore the relationship between rT1 value, Tmax, and onset time.<BR><B>RESULTS: </B>rT1 value was increased in diffusion reduced (1.42) and hypo-perfused regions (1.02, 1.06, 1.12, 1.27, Tmax 4-6 s, 6-8 s, 8-10 s, > 10 s, respectively; all different from 1, P < 0.001). rT1 value was positively correlated with Tmax (rs = 0.61, P < 0.001) and onset time in area with reduced diffusion (rs = 0.39, P = 0.014).<BR><B>CONCLUSIONS: </B>Increased rT1 value in different hypo-perfused brain regions using T1 mapping derived by STAGE may reflect the edema; it was associated with the severity of Tmax and showed a weak correlation with the onset time in diffusion reduced areas.