Abstract：
Direct oral anticoagulants (DOACs) are tending to supplant antivitamin K inhibitors (VKAs) in their common indications, dominated in elderly patients by atrial fibrillation and venous thromboembolism. Nevertheless, it remains necessary to know how best to use VKAs for which there are still indications. It is also important not to assume that AODs can be prescribed without risk, while ignoring certain particularities in their handling, particularly in the most fragile patients with co-morbidities and multiple medications.
摘要：
直接口服抗凝剂（DOAC）在其常见适应症中倾向于取代抗维生素K抑制剂（VKAs），老年患者以房颤和静脉血栓栓塞为主。然而，仍然有必要知道如何最好地使用仍然有迹象的VKAs。同样重要的是，不要假设可以无风险地规定AOD，在处理它们时忽略了某些特殊性，特别是在最脆弱的患者有并发症和多种药物。
