Abstract：
BACKGROUND: Previous observational studies have reported inconsistent findings on the association between consumption of sugar-sweetened soft drinks (SSSDs) and the risk of gastrointestinal (GI) cancer. This study investigated the associations between SSSD consumption and the risk of GI cancer using a systematic review and meta-analysis.
METHODS: Observational epidemiological studies were searched from the PubMed and EMBASE databases until June 2021. We conducted a meta-analysis of all included studies and subgroup meta-analyses based on various factors.
RESULTS: In a meta-analysis of 27 studies with nine case-control studies and 18 cohort studies, the consumption of SSSDs was modestly associated with an increased risk of GI cancer (odds ratio [OR]/relative risk [RR]: 1.08; 95% confidence interval [CI]: 1.01-1.16), with a significant positive dose-response relationship. In the subgroup meta-analysis by study design, there was a significant positive association between the consumption of SSSDs and GI cancer in cohort studies (RR: 1.11; 95% CI: 1.03-1.20; n = 18), but not in case-control studies. In the subgroup meta-analysis by type of cancer, consumption of SSSDs was significantly associated with an increased risk of colorectal cancer (OR/RR: 1.13; 95% CI: 1.07-1.19).
CONCLUSIONS: This meta-analysis suggests that SSSD consumption significantly increases the risk of GI cancer, specifically colorectal cancer.
METHODS: Observational epidemiological studies were searched from the PubMed and EMBASE databases until June 2021. We conducted a meta-analysis of all included studies and subgroup meta-analyses based on various factors.
RESULTS: In a meta-analysis of 27 studies with nine case-control studies and 18 cohort studies, the consumption of SSSDs was modestly associated with an increased risk of GI cancer (odds ratio [OR]/relative risk [RR]: 1.08; 95% confidence interval [CI]: 1.01-1.16), with a significant positive dose-response relationship. In the subgroup meta-analysis by study design, there was a significant positive association between the consumption of SSSDs and GI cancer in cohort studies (RR: 1.11; 95% CI: 1.03-1.20; n = 18), but not in case-control studies. In the subgroup meta-analysis by type of cancer, consumption of SSSDs was significantly associated with an increased risk of colorectal cancer (OR/RR: 1.13; 95% CI: 1.07-1.19).
CONCLUSIONS: This meta-analysis suggests that SSSD consumption significantly increases the risk of GI cancer, specifically colorectal cancer.
摘要：
背景：先前的观察性研究报道了关于食用含糖软饮料（SSSD）与胃肠道（GI）癌症风险之间关系的不一致发现。这项研究使用系统评价和荟萃分析调查了SSSD消耗与胃肠道癌症风险之间的关联。
方法：从PubMed和EMBASE数据库检索观察性流行病学研究，直至2021年6月。我们对所有纳入的研究和基于各种因素的亚组荟萃分析进行了荟萃分析。
结果：在对27项研究，9项病例对照研究和18项队列研究的荟萃分析中，SSSDs的消耗与胃肠道癌风险增加有一定的相关性(OR/RR:1.08;95%CI,1.01-1.16),具有显著的正剂量-反应关系。在通过研究设计进行的亚组荟萃分析中，在队列研究中，SSSD的消耗与胃肠道癌症之间存在显着正相关(RR，1.11；95%CI，1.03-1.20；n=18），但在病例对照研究中没有。在按癌症类型进行的亚组荟萃分析中，使用SSSD与结直肠癌风险增加显著相关(OR/RR:1.13;95%CI,1.07~1.19).
结论：这项荟萃分析表明，食用SSSD会显著增加胃肠道癌症的风险，特别是结直肠癌。
方法：从PubMed和EMBASE数据库检索观察性流行病学研究，直至2021年6月。我们对所有纳入的研究和基于各种因素的亚组荟萃分析进行了荟萃分析。
结果：在对27项研究，9项病例对照研究和18项队列研究的荟萃分析中，SSSDs的消耗与胃肠道癌风险增加有一定的相关性(OR/RR:1.08;95%CI,1.01-1.16),具有显著的正剂量-反应关系。在通过研究设计进行的亚组荟萃分析中，在队列研究中，SSSD的消耗与胃肠道癌症之间存在显着正相关(RR，1.11；95%CI，1.03-1.20；n=18），但在病例对照研究中没有。在按癌症类型进行的亚组荟萃分析中，使用SSSD与结直肠癌风险增加显著相关(OR/RR:1.13;95%CI,1.07~1.19).
结论：这项荟萃分析表明，食用SSSD会显著增加胃肠道癌症的风险，特别是结直肠癌。
