PDF(Pubmed)
Abstract：
This paper presents a systematic review of studies investigating the effects of fatty acid supplementation in potentially preventing and treating sarcopenia. PubMed, Embase, and Web of Science databases were searched using the keywords \'fatty acid\' and \'sarcopenia\'. Results: A total of 14 clinical and 11 pre-clinical (including cell and animal studies) studies were included. Of the 14 clinical studies, 12 used omega-3 polyunsaturated fatty acids (PUFAs) as supplements, 1 study used ALA and 1 study used CLA. Seven studies combined the use of fatty acid with resistant exercises. Fatty acids were found to have a positive effect in eight studies and they had no significant outcome in six studies. The seven studies that incorporated exercise found that fatty acids had a better impact on elderlies. Four animal studies used novel fatty acids including eicosapentaenoic acid, trans-fatty acid, and olive leaf extraction as interventions. Three animal and four cell experiment studies revealed the possible mechanisms of how fatty acids affect muscles by improving regenerative capacity, reducing oxidative stress, mitochondrial and peroxisomal dysfunctions, and attenuating cell death. Conclusion: Fatty acids have proven their value in improving sarcopenia in pre-clinical experiments. However, current clinical studies show controversial results for its role on muscle, and thus the mechanisms need to be studied further. In the future, more well-designed randomized controlled trials are required to assess the effectiveness of using fatty acids in humans.
摘要：
本文对研究补充脂肪酸可能预防和治疗肌肉减少症的作用进行了系统的综述。PubMed,Embase,和WebofScience数据库使用关键词“脂肪酸”和“肌肉减少症”进行搜索。结果：共纳入14项临床研究和11项临床前（包括细胞和动物研究）研究。在14项临床研究中,12使用omega-3多不饱和脂肪酸（PUFA）作为补充剂，1项研究使用ALA，1项研究使用CLA。七项研究将脂肪酸的使用与抗性运动相结合。在8项研究中发现脂肪酸具有积极作用，在6项研究中没有显著结果。结合运动的七项研究发现，脂肪酸对老年人有更好的影响。四项动物研究使用了包括二十碳五烯酸在内的新型脂肪酸，反式脂肪酸，和橄榄叶提取作为干预措施。三个动物和四个细胞实验研究揭示了脂肪酸如何通过提高再生能力影响肌肉的可能机制，减少氧化应激，线粒体和过氧化物酶体功能障碍，减少细胞死亡。结论：脂肪酸在临床前实验中已证明其在改善肌少症方面的价值。然而,目前的临床研究表明其对肌肉的作用有争议，因此，机制需要进一步研究。在未来,需要更精心设计的随机对照试验来评估人体使用脂肪酸的有效性.
