Abstract：
UNASSIGNED: Multiple myeloma (MM) is a malignant disease characterized by a single clonal proliferation of B cell-derived plasma cells in the bone marrow. It is the second most common haematologic malignancy in adults. The objective of this retrospective study is to evaluate the diagnostic and prognostic value of haematologic parameters in MM.
UNASSIGNED: The difference of NLR/ALB ratio (NAR) and NLR/HDL-C ratio (NHR) between the 151 newly diagnosed MM patients and 153 healthy controls was compared. According to NAR and NHR cutoff values obtained from the ROC curve, MM patients were divided into low group and high group. The differences in hematological parameters and survival time between the two groups were compared. Independent prognostic analysis was performed using Cox proportional hazard regression model.
UNASSIGNED: The NAR and NHR values in MM group were significantly higher than those in control group (P < 0.001). Higher NAR levels were significantly associated with lower albumin (ALB), higher β2 microglobulin(β2-MG), higher creatinine (Crea), and highe ISS stage (All P<0.05). High NHR group was significantly correlated with age , β2-MG and ISS stage (All P<0.05). In high NAR or NHR groups, OS and DFS was significantly shortened and the prognosis was poor (P < 0.05). Multivariate analysis showed that PLT, ISS stage and NAR were independent prognostic indicators of OS in MM patients, while ALB, PLT and NAR were independent prognostic factors of DFS.
UNASSIGNED: NAR and NHR are inexpensive, readily available diagnostic indicators for MM, and NAR is an independent prognostic factor for MM.
UNASSIGNED: The difference of NLR/ALB ratio (NAR) and NLR/HDL-C ratio (NHR) between the 151 newly diagnosed MM patients and 153 healthy controls was compared. According to NAR and NHR cutoff values obtained from the ROC curve, MM patients were divided into low group and high group. The differences in hematological parameters and survival time between the two groups were compared. Independent prognostic analysis was performed using Cox proportional hazard regression model.
UNASSIGNED: The NAR and NHR values in MM group were significantly higher than those in control group (P < 0.001). Higher NAR levels were significantly associated with lower albumin (ALB), higher β2 microglobulin(β2-MG), higher creatinine (Crea), and highe ISS stage (All P<0.05). High NHR group was significantly correlated with age , β2-MG and ISS stage (All P<0.05). In high NAR or NHR groups, OS and DFS was significantly shortened and the prognosis was poor (P < 0.05). Multivariate analysis showed that PLT, ISS stage and NAR were independent prognostic indicators of OS in MM patients, while ALB, PLT and NAR were independent prognostic factors of DFS.
UNASSIGNED: NAR and NHR are inexpensive, readily available diagnostic indicators for MM, and NAR is an independent prognostic factor for MM.
摘要：
■多发性骨髓瘤（MM）是一种恶性疾病，其特征在于骨髓中B细胞衍生的浆细胞的单克隆增殖。它是成人第二常见的血液恶性肿瘤。这项回顾性研究的目的是评估MM中血液学参数的诊断和预后价值。
■比较了151例新诊断的MM患者和153例健康对照者的NLR/ALB比值（NAR）和NLR/HDL-C比值（NHR）的差异。根据从ROC曲线获得的NAR和NHR截止值，MM患者分为低组和高组。比较两组患者血液学指标和生存时间的差异。采用Cox比例风险回归模型进行独立预后分析。
■MM组的NAR和NHR值均显著高于对照组(P<0.001)。较高的NAR水平与较低的白蛋白（ALB）显着相关，较高的β2微球蛋白（β2-MG），较高的肌酐（Crea），ISS分期较高(均P<0.05)。高NHR组与年龄显著相关,β2-MG与ISS分期(均P<0.05)。在高NAR或NHR组中，OS和DFS明显缩短,预后差(P<0.05)。多因素分析显示,ISS分期和NAR是MM患者OS的独立预后指标,而ALB,PLT和NAR是影响DFS的独立预后因素。
■NAR和NHR价格低廉，随时可用的MM诊断指标，NAR是MM的独立预后因素。
■比较了151例新诊断的MM患者和153例健康对照者的NLR/ALB比值（NAR）和NLR/HDL-C比值（NHR）的差异。根据从ROC曲线获得的NAR和NHR截止值，MM患者分为低组和高组。比较两组患者血液学指标和生存时间的差异。采用Cox比例风险回归模型进行独立预后分析。
■MM组的NAR和NHR值均显著高于对照组(P<0.001)。较高的NAR水平与较低的白蛋白（ALB）显着相关，较高的β2微球蛋白（β2-MG），较高的肌酐（Crea），ISS分期较高(均P<0.05)。高NHR组与年龄显著相关,β2-MG与ISS分期(均P<0.05)。在高NAR或NHR组中，OS和DFS明显缩短,预后差(P<0.05)。多因素分析显示,ISS分期和NAR是MM患者OS的独立预后指标,而ALB,PLT和NAR是影响DFS的独立预后因素。
■NAR和NHR价格低廉，随时可用的MM诊断指标，NAR是MM的独立预后因素。
