■本研究旨在探讨单核细胞与高密度脂蛋白胆固醇比值(MHR)的预测价值,中性粒细胞与高密度脂蛋白胆固醇比率(NHR),C反应蛋白与淋巴细胞比率(CLR),和C反应蛋白与白蛋白比值(CAR)治疗2型糖尿病(T2DM)患者的活动性肺结核(APTB)。
■共有991名活动性肺结核(APTB)患者(201名T2DM)在结核病科住院,武汉市金银滩医院,同济医学院,包括华中科技大学。收集血常规检查指标和生化指标,计算MHR,NHR,CLR,和汽车。皮尔逊相关分析,单因素Logistic回归分析,受试者工作特征(ROC)曲线分析评估MHR的预测价值,NHR,CLR,和CAR用于APTB-T2DM患者。
■MHR的水平,NHR,CLR,APTB-T2DM患者的CAR明显高于APTB-非T2DM患者(P<0.05)。此外,MHR,NHR,CLR,在整个研究人群中,CAR与空腹血糖呈正相关。然而,在APTB-T2DM患者中,MHR,NHR,和CAR与空腹血糖无关,仅CLR与空腹血糖呈正相关。预测APTB-T2DM患者MHR的曲线下面积(AUC),NHR,CLR,CAR分别为0.632、0.72、0.715和0.713。Further,单因素Logistic回归分析表明,MHR越高,NHR,CLR,CAR是APTB-T2DM的独立危险因素(P<0.01)。MHR,NHR,CLR,和CAR四分位数用于将APTB患者分为四组进行进一步分析。APTB个体中T2DM的患病率明显高于MHR,NHR,CLR,CAR值升高(P<0.05)。
■MHR,NHR,CLR,和CAR是简单可行的炎症参数,可用于评估APTB中的T2DM。APTB患者诊断为T2DM的可能性越大,MHR越高,NHRCLR,和CAR值。因此,APTB检查中应更多关注该指标。
UNASSIGNED: This study was to explore the predictive value of monocyte to high-density lipoprotein cholesterol ratio (MHR), neutrophils to high-density lipoprotein cholesterol ratio (
NHR), C-reactive protein-to-lymphocyte ratio (CLR), and C-reactive protein-to-albumin ratio (CAR) for type 2 diabetes mellitus (T2DM) in patients with active pulmonary tuberculosis (APTB).
UNASSIGNED: A total of 991 active pulmonary tuberculosis (APTB) patients (201 with T2DM) were hospitalized in the Department of Tuberculosis, Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology were included. The routine blood examination indicators and biochemical parameters were collected to calculate MHR,
NHR, CLR, and CAR. The Pearson correlation analysis, Univariate Logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were performed to assess the predictive value of MHR,
NHR, CLR, and CAR for APTB-T2DM patients.
UNASSIGNED: The levels of MHR, NHR, CLR, and CAR in the APTB-T2DM patients were significantly higher than in the APTB-no T2DM patients (P < 0.05). Additionally, the MHR,
NHR, CLR, and CAR have a positive correlation with fasting blood glucose in the whole study population. However, in the APTB-T2DM patients, MHR,
NHR, and CAR were not correlated with fasting blood glucose, and only CLR was positively correlated with fasting blood glucose. The area under curve (AUC) predicting APTB-T2DM patients of the MHR, NHR, CLR, and CAR was 0.632, 0.72, 0.715, and 0.713, respectively. Further, univariate logistic regression analyses showed that the higher MHR, NHR, CLR, and CAR were independent risk factors for APTB-T2DM (P < 0.01). The MHR, NHR, CLR, and CAR quartiles were used to divide the APTB patients into four groups for further analysis. The prevalence of T2DM was significantly higher in APTB individuals as MHR, NHR, CLR, and CAR values increased (P < 0.05).
UNASSIGNED: MHR, NHR, CLR, and CAR are simple and practicable inflammatory parameters that could be used for assessing T2DM in APTB. APTB patients have a greater possibility to be diagnosed with T2DM with the higher MHR, NHR CLR, and CAR values. Therefore, more attention should be given to the indicator in the examination of APTB.