PDF(Pubmed)
Abstract：
Postoperative nausea and vomiting (PONV) is a distressing symptom that patients often complain of even after less invasive surgery such as laparoscopic surgery (LS). If PONV is not well managed, patient recovery and postoperative quality of life are adversely affected. Although various drugs have been administered to prevent PONV, their effectiveness is limited, and adverse effects are numerous. Although herbal medicines have been widely used to manage various gastrointestinal symptoms, including nausea and vomiting, scientific evidence of their effects is lacking. This protocol is intended for a systematic review to analyse the efficacy and safety of Chinese herbal medicines for PONV after LS through a meta-analysis.
Randomised controlled trials, reported until June 2022, will be retrieved from electronic databases such as Medline, EMBASE and Cochrane Library. We will compare the effects of herbal medicine in patients presenting with PONV after LS with those of Western medicine, placebo and no treatment. If sufficient studies are identified, we will evaluate the combined effects of herbal and Western medicine. The incidence of nausea and vomiting will be considered the primary outcome. Secondary outcomes will include the intensity of complaints, quality of life and incidence of adverse events. Two independent reviewers will collect data based on the Preferred Reporting Items for Systematic Review and Meta-Analyses statement, evaluate the quality of each study using the Cochrane risk-of-bias tool and synthesise the results via meta-analysis, if possible.
Ethical approval is not required for this review. The results of this study will be disseminated to peer-reviewed journals and posters.
CRD42022345749.
Randomised controlled trials, reported until June 2022, will be retrieved from electronic databases such as Medline, EMBASE and Cochrane Library. We will compare the effects of herbal medicine in patients presenting with PONV after LS with those of Western medicine, placebo and no treatment. If sufficient studies are identified, we will evaluate the combined effects of herbal and Western medicine. The incidence of nausea and vomiting will be considered the primary outcome. Secondary outcomes will include the intensity of complaints, quality of life and incidence of adverse events. Two independent reviewers will collect data based on the Preferred Reporting Items for Systematic Review and Meta-Analyses statement, evaluate the quality of each study using the Cochrane risk-of-bias tool and synthesise the results via meta-analysis, if possible.
Ethical approval is not required for this review. The results of this study will be disseminated to peer-reviewed journals and posters.
CRD42022345749.
摘要：
背景：术后恶心和呕吐（PONV）是一种令人痛苦的症状，即使在腹腔镜手术（LS）等微创手术后，患者也经常抱怨。如果PONV管理不好，患者的恢复和术后生活质量受到不利影响。尽管已经服用了各种药物来预防PONV，它们的有效性是有限的，副作用很多。虽然草药已被广泛用于治疗各种胃肠道症状，包括恶心和呕吐,缺乏有关其影响的科学证据。该方案旨在进行系统评价，以通过荟萃分析分析中草药治疗LS后PONV的疗效和安全性。
方法：随机对照试验，报告到2022年6月，将从Medline等电子数据库中检索，EMBASE和Cochrane图书馆。我们将比较LS后出现PONV的患者与西药的效果，安慰剂和不治疗。如果有足够的研究，我们将评估中草药和西药的联合作用。恶心和呕吐的发生率将被认为是主要结果。次要结果将包括投诉的强度，生活质量和不良事件发生率。两名独立审核员将根据系统审查和荟萃分析声明的首选报告项目收集数据，使用Cochrane偏差风险工具评估每项研究的质量，并通过荟萃分析综合结果，如果可能的话。
背景：本审查不需要道德批准。这项研究的结果将传播给同行评审的期刊和海报。
■CRD42022345749。
方法：随机对照试验，报告到2022年6月，将从Medline等电子数据库中检索，EMBASE和Cochrane图书馆。我们将比较LS后出现PONV的患者与西药的效果，安慰剂和不治疗。如果有足够的研究，我们将评估中草药和西药的联合作用。恶心和呕吐的发生率将被认为是主要结果。次要结果将包括投诉的强度，生活质量和不良事件发生率。两名独立审核员将根据系统审查和荟萃分析声明的首选报告项目收集数据，使用Cochrane偏差风险工具评估每项研究的质量，并通过荟萃分析综合结果，如果可能的话。
背景：本审查不需要道德批准。这项研究的结果将传播给同行评审的期刊和海报。
■CRD42022345749。
