PDF(Pubmed)
Abstract：
Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.
摘要：
核型间质性肾炎（KIN）是以肾小管上皮核增大为特征的慢性间质性肾炎的罕见原因。在肾移植中报告的第一例KIN是在2019年。这里,我们报告了2名兄弟中的首例KIN病例，他们接受了来自2名不同无关活体供者的肾脏。一名男性肾脏移植受者，以局灶性节段性肾小球硬化为原始肾脏疾病，表现为移植物受损和蛋白尿，移植活检显示KIN.该患者有一个兄弟，他也是肾移植受者，有一次移植物受损，也被诊断为KIN。
