{Reference Type}: Review
{Title}: Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature.
{Author}: El-Husseiny Moustafa F;Nagy E;Elwasif SM;Sobh M;
{Journal}: BMC Nephrol
{Volume}: 24
{Issue}: 1
{Year}: 2023 05 19
{Factor}: 2.585
{DOI}: 10.1186/s12882-023-03185-3
{Abstract}: Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.