饮食与急性肾小管间质性肾炎之间存在不确定性。饮食因素作为暴露,包括酒精的摄入,牛肉,非油性鱼,新鲜水果,油性鱼,干果,咖啡,沙拉/生蔬菜,麦片,茶,水,盐,煮熟的蔬菜,奶酪,家禽,猪肉,羊肉/羊肉,面包,加工肉类是从英国生物银行提取的。急性肾小管间质性肾炎作为从FinnGen生物库提取的结果。这种分析的3种主要方法是加权中位数,逆方差加权(IVW),和MR-Egger方法。使用CochranQ测试测量异质性。MR-PRESSO方法用于识别可能的异常值。通过采用留一法分析评估IVW方法的稳健性。根据IVW方法,加工肉类摄入量(OR=0.485;P=0.00152),非油性鱼类摄入量(OR=0.396;P=.0454),油性鱼类摄入量(OR=0.612;P=.00161),和干果摄入量(OR=0.536;P=.00648)降低了急性肾小管间质性肾炎的风险。其他饮食因素未显示与急性肾小管间质性肾炎有因果关系。这项研究表明,加工肉类的摄入量,非油性鱼,油性鱼,和干果均降低了急性肾小管间质性肾炎的风险。
Uncertainty exists regarding the association between diet and acute tubulointerstitial nephritis. Dietary factors served as exposures, including intake of alcohol, beef, non-oily fish, fresh fruit, oily fish, dried fruit, coffee, salad/raw vegetable, cereal, tea, water, salt, cooked vegetable, cheese, poultry, pork, Lamb/mutton, bread, and processed meat were extracted from the UK Biobank. Acute tubulointerstitial nephritis served as the outcome extracted from the FinnGen biobank. The 3 main methods of this analysis were weighted median, inverse-variance-weighted (IVW), and MR-Egger methods. The heterogeneity was measured employing Cochran Q test. The MR-PRESSO method was employed to identify possible outliers. The robustness of the IVW method was evaluated by employing the leave-one-out analysis. According to the IVW method, processed meat intake (OR = 0.485; P = .00152), non-oily fish intake (OR = 0.396; P = .0454), oily fish intake (OR = 0.612; P = .00161), and dried fruit intake (OR = 0.536; P = .00648) reduced the risk of acute tubulointerstitial nephritis. Other dietary factors were not shown to be causally related to acute tubulointerstitial nephritis. This study revealed that intake of processed meat, non-oily fish, oily fish, and dried fruit all decreased the risk of acute tubulointerstitial nephritis.