%0 Review
%T Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature.
%A El-Husseiny Moustafa F
%A Nagy E
%A Elwasif SM
%A Sobh M
%J BMC Nephrol
%V 24
%N 1
%D 2023 05 19
%M 37208636
%F 2.585
%R 10.1186/s12882-023-03185-3
%X Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.