METHODS: Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups.
RESULTS: The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group.
CONCLUSIONS: LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023.
方法:本研究纳入了在德岛大学医院接受IHCC初次肝切除术的46例患者。使用切除的标本进行LAT1和磷酸化Akt(p-AKT)的免疫组织化学分析。临床病理因素,包括预后,在LAT1高组和LAT1低组之间进行分析。
结果:与低LAT1组相比,高LAT1组表现出较高比例的导管周围浸润型和较高的癌胚抗原/糖类抗原19-9水平。多因素分析显示,LAT1高表达是无病生存的独立预后因素。此外,LAT1高组的p-AKT阳性比例高于LAT1低组.
结论:LAT1表达与IHCC的不良预后和较高的p-Akt表达相关。J.Med.投资。70:160-165,二月,2023年。