Abstract：
BACKGROUND: Amino acid transporters, such as L-type amino acid transporter 1 (LAT1), have an effect on tumor growth, metastasis, and survival of various solid tumors. However, the role of LAT1 in patients with intrahepatic cholangiocarcinoma (IHCC) remains unknown.
METHODS: Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups.
RESULTS: The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group.
CONCLUSIONS: LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023.
METHODS: Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups.
RESULTS: The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group.
CONCLUSIONS: LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023.
摘要：
背景：氨基酸转运蛋白，如L型氨基酸转运蛋白1（LAT1），对肿瘤生长有影响，转移,和各种实体瘤的存活率。然而,LAT1在肝内胆管癌(IHCC)患者中的作用尚不清楚.
方法：本研究纳入了在德岛大学医院接受IHCC初次肝切除术的46例患者。使用切除的标本进行LAT1和磷酸化Akt（p-AKT）的免疫组织化学分析。临床病理因素,包括预后，在LAT1高组和LAT1低组之间进行分析。
结果：与低LAT1组相比，高LAT1组表现出较高比例的导管周围浸润型和较高的癌胚抗原/糖类抗原19-9水平。多因素分析显示，LAT1高表达是无病生存的独立预后因素。此外，LAT1高组的p-AKT阳性比例高于LAT1低组.
结论：LAT1表达与IHCC的不良预后和较高的p-Akt表达相关。J.Med.投资。70:160-165,二月,2023年。
方法：本研究纳入了在德岛大学医院接受IHCC初次肝切除术的46例患者。使用切除的标本进行LAT1和磷酸化Akt（p-AKT）的免疫组织化学分析。临床病理因素,包括预后，在LAT1高组和LAT1低组之间进行分析。
结果：与低LAT1组相比，高LAT1组表现出较高比例的导管周围浸润型和较高的癌胚抗原/糖类抗原19-9水平。多因素分析显示，LAT1高表达是无病生存的独立预后因素。此外，LAT1高组的p-AKT阳性比例高于LAT1低组.
结论：LAT1表达与IHCC的不良预后和较高的p-Akt表达相关。J.Med.投资。70:160-165,二月,2023年。
