■临床,胆管癌的诊断和治疗通常根据发生的位置而有所不同,研究很少考虑不同病理类型之间的差异。大型和中型肝内胆管的胆管癌大多是粘液性的,而在小型胆管中没有;粘液性肝外胆管癌也比粘液性肝内胆管癌更常见。然而,目前尚不清楚这些病理类型的差异是否与预后有关。
■从监测中分析了总共22509名患者的数据,流行病学,和最终结果计划数据库,其中22299例患者被诊断为常见的腺胆管癌,而210例被诊断为黏液性胆管癌。基于倾向得分匹配(PSM)分析,在这两组临床上,人口统计学,和治疗特征进行了对比。使用Cox和LASSO回归分析和Kaplan-Meier存活曲线分析数据。最终,我们建立了总生存期(OS)和癌症特异性生存期(CSS)相关的预后模型,并在试验和外部数据集进行了验证,并创建了列线图来预测这些患者的预后.
■粘液性胆管癌和腺胆管癌的预后无差异。因此,我们构建了可同时用于粘液性和胆管癌的预后模型和列线图。通过比较9个独立的关键特征,即年龄,肿瘤大小,原发性肿瘤的数量,AJCC阶段,Grade,淋巴结状态,转移,手术和化疗,计算每个个体的风险评分.通过在OS和CSS预后模型中整合这两种病理类型,可以在多个数据集上获得有效的预后预测结果(OS:AUC0.70-0.87;CSS:AUC0.74-0.89)。
■年龄,肿瘤大小,原发性肿瘤的数量,AJCC阶段,Grade,淋巴结状态,转移,手术和化疗是黏液性和普通胆管癌患者OS或CSS的独立预后因素。可同时用于粘液性和腺胆管癌的列线图在胆管癌的临床实践和管理中具有重要意义。
UNASSIGNED: Clinically, the diagnosis and treatment of cholangiocarcinoma are generally different according to the location of occurrence, and the studies rarely consider the differences between different pathological types. Cholangiocarcinomas in large- and middle-sized intrahepatic bile ducts are mostly mucinous, while in small sized bile duct are not; mucinous extrahepatic cholangiocarcinomas are also more common than mucinous intrahepatic cholangiocarcinoma. However, it is unclear whether these pathological type differences are related to the prognosis.
UNASSIGNED: Data of total 22509 patients was analyzed from Surveillance, Epidemiology, and End Results program database out of which 22299 patients were diagnosed with common adeno cholangiocarcinoma while 210 were diagnosed with mucinous cholangiocarcinoma. Based on the propensity score matching (PSM) analysis, between these two groups\' clinical, demographic, and therapeutic features were contrasted. The data were analyzed using Cox and LASSO regression analysis and Kaplan-Meier survival curves. Ultimately, overall survival (OS) and cancer specific survival (CSS) related prognostic models were established and validated in test and external datasets and nomograms were created to forecast these patients\' prognosis.
UNASSIGNED: There was no difference in prognosis between mucinous cholangiocarcinoma and adeno cholangiocarcinoma. Therefore, we constructed prognostic model and nomogram that can be used for mucinous and adeno cholangiocarcinoma at the same time. By comparing the 9 independent key characteristics i.e. Age, tumor size, the number of primary tumors, AJCC stage, Grade, lymph node status, metastasis, surgery and chemotherapy, risk scores were calculated for each individual. By integrating these two pathological types in OS and CSS prognostic models, effective prognosis prediction results could be achieved in multiple datasets (OS: AUC 0.70-0.87; CSS: AUC 0.74-0.89).
UNASSIGNED: Age, tumor size, the number of primary tumors, AJCC stage, Grade, lymph node status, metastasis, surgery and chemotherapy are the independent prognostic factors in OS or CSS of the patients with mucinous and ordinary cholangiocarcinoma. Nomogram that can be used for mucinous and adeno cholangiocarcinoma at the same time is of significance in clinical practice and management of cholangiocarcinoma.