%0 Journal Article
%T Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma.
%A Selenge B
%A Yamada S
%A Morine Y
%A Ikemoto T
%A Saito Y
%A Takasu C
%A Teraoku H
%A Okikawa S
%A Shimada M
%J J Med Invest
%V 70
%N 1
%D 2023
%M 37164714
暂无%R 10.2152/jmi.70.160
%X <B>BACKGROUND: </B>Amino acid transporters, such as L-type amino acid transporter 1 (LAT1), have an effect on tumor growth, metastasis, and survival of various solid tumors. However, the role of LAT1 in patients with intrahepatic cholangiocarcinoma (IHCC) remains unknown.<BR><B>METHODS: </B>Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups.<BR><B>RESULTS: </B>The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group.<BR><B>CONCLUSIONS: </B>LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023.