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Abstract：
This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia-niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leukaemia cells, this poses as a key clinical challenge that hinders management of this disease. Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets. Additionally, we discuss microenvironment-driven treatment resistance and relapse, and elaborate the role of CDH2-mediated cancer cell protection from chemotherapy. Finally, we review emerging therapeutic approaches that directly target CDH2-mediated adhesive interactions between the BM cells and leukaemia cells.
摘要：
这篇综述讨论了急性小儿白血病的当前研究，白血病骨髓（BM）微环境和最近发现的靶向白血病-小生境相互作用的治疗机会。肿瘤微环境在赋予白血病细胞治疗抗性中起着不可或缺的作用。这是阻碍本病治疗的关键临床挑战.在这里，我们专注于细胞粘附分子N-钙黏着蛋白（CDH2）在恶性BM微环境中的作用以及可能作为治疗靶标的相关信号通路。此外,我们讨论了微环境驱动的治疗抵抗和复发，并阐述CDH2介导的癌细胞对化疗的保护作用。最后,我们回顾了新兴的直接靶向CDH2介导的BM细胞和白血病细胞之间的粘附相互作用的治疗方法.
