PDF(Pubmed)
Abstract：
Sleep disorders are common in Parkinson\'s disease (PD) and include alterations in sleep-related EEG oscillations.
This case-control study tested the hypothesis that patients with PD would have a lower density of Scalp-Slow Wave (SW) oscillations and higher slow-to-fast frequencies ratio in rapid eye movement (REM) sleep than non-PD controls. Other sleep-related quantitative EEG (qEEG) features were also examined, including SW morphology, sleep spindles, and Scalp-SW spindle phase-amplitude coupling.
Polysomnography (PSG)-derived sleep EEG was compared between PD participants (n = 56) and non-PD controls (n = 30). Following artifact rejection, sleep qEEG analysis was performed in frontal and central leads. Measures included SW density and morphological features of SW and sleep spindles, SW-spindle phase-amplitude coupling, and spectral power analysis in Non-REM (NREM) and REM. Differences in qEEG features between PD and non-PD controls were compared using two-tailed Welch\'s t-tests, and correction for multiple comparisons was performed per the Benjamini-Hochberg method.
SW density was lower in PD than in non-PD controls (F = 13.5, p\' = 0.003). The PD group also exhibited higher ratio of slow REM EEG frequencies (F = 4.23, p\' = 0.013), higher slow spindle peak frequency (F = 24.7, p\' < 0.002), and greater SW-spindle coupling angle distribution non-uniformity (strength) (F = 7.30, p\' = 0.034).
This study comprehensively evaluates sleep qEEG including SW-spindle phase amplitude coupling in PD compared to non-PD controls. These findings provide novel insights into how neurodegenerative disease disrupts electrophysiological sleep rhythms. Considering the role of sleep oscillatory activity on neural plasticity, future studies should investigate the influence of these qEEG markers on cognition in PD.
This case-control study tested the hypothesis that patients with PD would have a lower density of Scalp-Slow Wave (SW) oscillations and higher slow-to-fast frequencies ratio in rapid eye movement (REM) sleep than non-PD controls. Other sleep-related quantitative EEG (qEEG) features were also examined, including SW morphology, sleep spindles, and Scalp-SW spindle phase-amplitude coupling.
Polysomnography (PSG)-derived sleep EEG was compared between PD participants (n = 56) and non-PD controls (n = 30). Following artifact rejection, sleep qEEG analysis was performed in frontal and central leads. Measures included SW density and morphological features of SW and sleep spindles, SW-spindle phase-amplitude coupling, and spectral power analysis in Non-REM (NREM) and REM. Differences in qEEG features between PD and non-PD controls were compared using two-tailed Welch\'s t-tests, and correction for multiple comparisons was performed per the Benjamini-Hochberg method.
SW density was lower in PD than in non-PD controls (F = 13.5, p\' = 0.003). The PD group also exhibited higher ratio of slow REM EEG frequencies (F = 4.23, p\' = 0.013), higher slow spindle peak frequency (F = 24.7, p\' < 0.002), and greater SW-spindle coupling angle distribution non-uniformity (strength) (F = 7.30, p\' = 0.034).
This study comprehensively evaluates sleep qEEG including SW-spindle phase amplitude coupling in PD compared to non-PD controls. These findings provide novel insights into how neurodegenerative disease disrupts electrophysiological sleep rhythms. Considering the role of sleep oscillatory activity on neural plasticity, future studies should investigate the influence of these qEEG markers on cognition in PD.
摘要：
背景：睡眠障碍在帕金森病（PD）中很常见，包括与睡眠相关的EEG振荡的改变。
目的：这项病例对照研究检验了以下假设：与非PD对照相比，PD患者在快速眼动（REM）睡眠中的头皮慢波（SW）振荡密度较低，慢速与快速频率比较高。还检查了其他与睡眠相关的定量EEG（qEEG）特征，包括SW形态，睡眠纺锤波，和Scalp-SW主轴相位-振幅耦合。
方法：比较了PD参与者（n=56）和非PD对照组（n=30）之间多导睡眠图（PSG）衍生的睡眠EEG。排除伪影后，在额叶和中央导联中进行睡眠qEEG分析。措施包括SW密度和SW和睡眠纺锤的形态特征，SW-主轴相位-振幅耦合，以及非快速眼动(NREM)和快速眼动中的频谱功率分析。使用双尾Welcht检验比较PD和非PD对照之间的qEEG特征差异，根据Benjamini-Hochberg方法对多重比较进行校正。
结果：PD中的SW密度低于非PD对照（F=13.5，p'=0.003）。PD组还表现出较高的慢速REMEEG频率比率（F=4.23，p'=0.013），较高的慢速主轴峰值频率(F=24.7，p'<0.002)，和更大的SW-主轴耦合角分布不均匀性（强度）（F=7.30，p'=0.034）。
结论：与非PD对照相比，本研究全面评估了PD中的睡眠qEEG，包括SW-纺锤形相位振幅耦合。这些发现为神经退行性疾病如何破坏电生理睡眠节律提供了新的见解。考虑到睡眠振荡活动对神经可塑性的作用，未来的研究应该研究这些qEEG标记对PD认知的影响。
目的：这项病例对照研究检验了以下假设：与非PD对照相比，PD患者在快速眼动（REM）睡眠中的头皮慢波（SW）振荡密度较低，慢速与快速频率比较高。还检查了其他与睡眠相关的定量EEG（qEEG）特征，包括SW形态，睡眠纺锤波，和Scalp-SW主轴相位-振幅耦合。
方法：比较了PD参与者（n=56）和非PD对照组（n=30）之间多导睡眠图（PSG）衍生的睡眠EEG。排除伪影后，在额叶和中央导联中进行睡眠qEEG分析。措施包括SW密度和SW和睡眠纺锤的形态特征，SW-主轴相位-振幅耦合，以及非快速眼动(NREM)和快速眼动中的频谱功率分析。使用双尾Welcht检验比较PD和非PD对照之间的qEEG特征差异，根据Benjamini-Hochberg方法对多重比较进行校正。
结果：PD中的SW密度低于非PD对照（F=13.5，p'=0.003）。PD组还表现出较高的慢速REMEEG频率比率（F=4.23，p'=0.013），较高的慢速主轴峰值频率(F=24.7，p'<0.002)，和更大的SW-主轴耦合角分布不均匀性（强度）（F=7.30，p'=0.034）。
结论：与非PD对照相比，本研究全面评估了PD中的睡眠qEEG，包括SW-纺锤形相位振幅耦合。这些发现为神经退行性疾病如何破坏电生理睡眠节律提供了新的见解。考虑到睡眠振荡活动对神经可塑性的作用，未来的研究应该研究这些qEEG标记对PD认知的影响。
