■睡眠质量与高血压风险之间的联系已经确立。然而,关于客观睡眠特征与高血压发病率之间特定剂量关系的研究仍然有限。本研究旨在探讨客观睡眠特征与高血压发病率之间的剂量关系。
■采用基于社区的前瞻性队列研究设计,使用睡眠心脏健康研究(SHHS)的数据。共有2,460人被纳入研究,其中780人患有高血压。收集基线个人特征和病史。通过多导睡眠图(PSG)获得客观的睡眠特征。采用多因素logistic回归模型进行分析。限制性三次样条(RCS)用于检查剂量关系关联。
■调整协变量后,第2阶段总睡眠持续时间的百分比(N2%)与高血压发病率呈正相关,而N3%与高血压发病率呈负相关,比值比(OR)=1.009,95%置信区间(CI)[1.001,1.018],P=0.037;OR=0.987,95%CI:[0.979,0.995],P分别为0.028。N2睡眠每增加10%,患高血压的风险增加9%,而N3睡眠减少3%相当于高血压发病率增加0.1%。在非抑郁亚组中,N2%与高血压之间的正相关具有统计学意义(OR=1.012,95CI,1.002,1.021,P=0.013,P交互作用=0.013).RCS表明,当N2%从38%到58%时,发生高血压的风险较低,此后迅速增加(P=0.002,非线性P=0.040)。高血压发病风险最低的是N3%发生在25%,15%以下或40%以上显着增加(P=0.001,非线性P=0.008)。
■N3%与高血压发病率呈负相关,N2%和高血压发病率呈正相关,特别是在非抑郁症患者中。这些关联表现出强烈的非线性剂量-反应关系。
UNASSIGNED: The link between sleep quality and hypertension risk is well-established. However, research on the specific dose-relationship between objective sleep characteristics and hypertension incidence remains limited. This study aims to explore the dose-relationship association between objective sleep characteristics and hypertension incidence.
UNASSIGNED: A community-based prospective cohort study design was employed using data from the Sleep Heart Health Study (SHHS). A total of 2,460 individuals were included in the study, of which 780 had hypertension. Baseline personal characteristics and medical history were collected. Objective sleep characteristics were obtained through polysomnography (PSG). Multivariate logistic regression models were utilized for analysis. Restricted cubic splines (RCS) were used to examine dose-relationship associations.
UNASSIGNED: After adjusting for covariates, the percentage of total sleep duration in stage 2 (N2%) was positively associated with hypertension incidence, while the N3% was negatively associated with hypertension incidence Odds ratio (OR) = 1.009, 95% confidence interval (CI) [1.001, 1.018], P = 0.037; OR = 0.987, 95% CI: [0.979, 0.995], P = 0.028, respectively. For every 10% increase in N2 sleep, the risk of developing hypertension increases by 9%, while a 3% decrease in N3 sleep corresponds to a 0.1% increase in the incidence of hypertension. In the subgroup of non-depression, a positive association between N2% and hypertension was significant statistically (OR = 1.012, 95%CI, 1.002, 1.021, P = 0.013, Pinteraction = 0.013). RCS demonstrated that the risk of developing hypertension was lower when N2% ranged from 38% to 58% and rapidly increased thereafter (P = 0.002, non-linear P = 0.040). The lowest risk for hypertension incidence risk of N3% occurring at 25%, and a significant increase below 15% or above 40% (P = 0.001, non-linear P = 0.008).
UNASSIGNED: There\'s a negative association between N3% and the incidence of hypertension, and a positive association between N2% and the incidence of hypertension, particularly among non-depression individuals. These associations exhibit strong non-linear dose-response relationships.