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Abstract：
A group of DNA viruses called parvoviruses that have significant effects on cancer therapy and genetic engineering applications. After passing through the cell membrane to reach the cytosol, it moves along the microtubule toward the nuclear membrane. The nuclear localization signal (NLS) is recognized by importin-beta (impβ) and other proteins from the complex outside the nuclear membrane and binds to enter the nucleus via the nuclear pore complex (NPC). There are two main pathways for viruses to enter the nucleus. The classical pathway is through the interaction of imp α and impβ with NLS via NPC. The other is the NPC mediated by the combination of impβ and it. While the capsid is introduced into the nucleus through classical nuclear transduction, there is also a transient nuclear membrane dissolution leading to passive transport into the nucleus, which has been proposed in recent years. This article mainly discusses several nuclear entry pathways and related proteins, providing a reference for subsequent research on viral entry pathways.
摘要：
一组称为细小病毒的DNA病毒，对癌症治疗和基因工程应用具有重大影响。穿过细胞膜到达细胞质后，它沿着微管向核膜移动。核定位信号（NLS）被来自核膜外复合物的importin-β（impβ）和其他蛋白质识别，并通过核孔复合物（NPC）结合进入细胞核。病毒进入细胞核有两种主要途径。经典途径是通过impα和impβ通过NPC与NLS的相互作用。另一种是由impβ和it的组合介导的NPC。当衣壳通过经典的核转导引入细胞核时，还存在短暂的核膜溶解，导致被动转运到细胞核中，这是近年来提出的。本文主要讨论了几种核进入途径和相关蛋白,病毒进入途径的后续研究提供参考。
