In this randomized, double-blind, placebo-controlled, and crossover trial, we aimed to test whether the administration of 800 mg GABA, dissolved in a drink, acutely affected visual working memory (VWM) maintenance, as well as temporal and spatial attention in healthy adults.
The participants were 32 young adults (16 females and 16 males). Working memory recall precision, spatial attention and temporal attention were measured by a delayed match-to-sample task, a visual search (VS) task and a speeded rapid serial visual presentation task, respectively. Participants completed two experimental sessions (GABA and Placebo) in randomized and counterbalanced order. In each session, 45 min after administration of the drink, they completed all three aforementioned cognitive tasks.
Linear mixed model analysis results showed that GABA increased VS time, compared to the placebo, but did not affect VS accuracy, temporal attention, nor VWM precision.
The results suggest that GABA increases VS time but does not affect temporal attention and memory, and that previously reported effects on cognition might rely on other functions.
■在这个随机的,双盲,安慰剂对照,和交叉试验,我们的目的是测试800毫克GABA的给药,溶解在饮料中,严重影响视觉工作记忆(VWM)的维护,以及健康成年人的时间和空间注意力。
■参与者是32名年轻人(16名女性和16名男性)。工作记忆召回精度,空间注意力和时间注意力是通过延迟匹配样本任务来测量的,视觉搜索(VS)任务和快速串行视觉呈现任务,分别。参与者以随机和平衡的顺序完成了两个实验课程(GABA和安慰剂)。在每个会话中,给药后45分钟,他们完成了上述三项认知任务。
■线性混合模型分析结果表明,GABA增加了VS时间,与安慰剂相比,但不影响VS准确性,时间注意力,也不是VWM精度。
■结果表明,GABA增加了VS时间,但不影响时间注意力和记忆,以前报道的对认知的影响可能依赖于其他功能。