Systemic Retinoids for Generalized Verrucosis Due to Congenital Immunodeficiency: Case Reports and Review of the Literature.

全身性维甲酸治疗先天性免疫缺陷引起的广泛性疣 ： 病例报告和文献复习。

• 影响指数: 4.141
• 发表时间: 03 2023 22
• 来源期刊: Genes (Basel)
• DOI: 10.3390/genes14030769
• PMID: 36981039
• 文章类型: Review
• 中科院分区: Q2
• 方向: 生物
• 作者列表: Kosumi H,Natsuga K,Yanagi T,Ujiie H

关键词: congenital immunodeficiency; generalized verrucosis; human papilloma virus; retinoids

Mesh: Humans; Retinoids / therapeutic use; Warts / drug therapy; Immunologic Deficiency Syndromes / complications drug therapy; Papillomavirus Infections; Papillomaviridae

Abstract

Generalized verrucosis (GV) is a group of immunodeficiency disorders accompanied by widespread human papillomavirus infection. We revisit two cases of GV due to congenital interleukin-7 deficiency successfully treated with systemic retinoids. We also present a review of the literature on the use of systemic retinoids to treat GV. Our review suggests that systemic retinoids are a safe and effective option for managing recalcitrant wart lesions in cases of GV.

摘要

广泛性疣状（GV）是一组免疫缺陷性疾病，伴有广泛的人乳头瘤病毒感染。我们重新审视了两例因先天性白介素7缺乏症而成功用全身性类维生素A治疗的GV病例。我们还对使用全身性类维生素A治疗GV的文献进行了综述。我们的评论表明，在GV病例中，全身性类维生素A是治疗顽固性疣病变的安全有效的选择。