%0 Review %T Systemic Retinoids for Generalized Verrucosis Due to Congenital Immunodeficiency: Case Reports and Review of the Literature. %A Kosumi H %A Natsuga K %A Yanagi T %A Ujiie H %J Genes (Basel) %V 14 %N 3 %D 03 2023 22 %M 36981039 %F 4.141 %R 10.3390/genes14030769 %X Generalized verrucosis (GV) is a group of immunodeficiency disorders accompanied by widespread human papillomavirus infection. We revisit two cases of GV due to congenital interleukin-7 deficiency successfully treated with systemic retinoids. We also present a review of the literature on the use of systemic retinoids to treat GV. Our review suggests that systemic retinoids are a safe and effective option for managing recalcitrant wart lesions in cases of GV.