METHODS: Bicentric retrospective analysis of consecutive cases of SUDI under 2 years of age were managed by two French SUDI referral centers with PMFP by RetCam (Clarity Medical Systems USA). PMFP were reviewed randomly, twice, by three independent ophthalmologists blinded for clinical data.
RESULTS: Thirty cases (60 eyes) were included. Median age was 3.5 months (interquartile [1.6; 6.0]). No child died of AHT. Image quality was sufficient to assert presence or absence of RH in 50 eyes (83%). Sufficient quality rate was significantly higher when the post-mortem interval was inferior to 18 h (91%, 42/46) as opposed to over 18 h (57%, 8/14, p=0.0096). RH were found in six eyes (10%), four children (13%), with excellent inter and intra-raters\' concordance (Cohen\'s Kappa from 0.81 [0.56-1.00] to 1.00 [1.00-1.00]).
CONCLUSIONS: PMFP can detect RH in case of SUDI and is a relevant systematic screening test to be carried out as soon as the deceased child arrives in the hospital. It can decrease the need of eye removal for pathological examination, but further studies are needed to define the best decision algorithm.
方法:双中心回顾性分析连续2岁以下的SUDI病例,由法国两个SUDI转诊中心通过RetCam(美国ClarityMedicalSystems)进行PMFP管理。
结果:30例60眼。
结论:PMFP可以在SUDI的情况下检测RH,并且是相关的系统筛查测试,将在死亡儿童到达医院后立即进行。