PDF(Pubmed)
Abstract：
The extensive and rapid development of the human brain during the first years of life complicates the postmortem diagnosis of brain edema in infancy. The aim of this study was to describe brain water content, the brain weight/body weight ratio, and the brain weight/head circumference ratio throughout the first years of life. Furthermore, we examined the relationship between these parameters and rs2075575 in the AQP4 gene. Our hypothesis was that dysregulated water homeostasis might be a risk factor for sudden infant death syndrome (SIDS), which may be reflected by increased water content in the brain. The study included 90 subjects with sudden unexpected death < 4 years of age: 22 cases of sudden infant death syndrome, 11 cases of sudden unexplained death in childhood, 47 cases of death due to disease, and 10 cases of accident/violent death. Brain water content, brain weight/body weight ratio, and brain weight/head circumference ratio were investigated according to corrected age, diagnosis group, attempt to resuscitate, and presence of brain edema. We found that brain water content and brain weight/body weight ratio were significantly reduced with increasing age, while brain weight/head circumference were increased. Brain weight/head circumference was correlated with brain water content. Cases with brain edema had a significantly higher brain weight/head circumference than the non-edematous cases. No differences were found between the diagnosis groups for any of the investigated parameters. In summary, the findings contribute to the current body of knowledge regarding brain growth during the first months of life.
摘要：
在生命的最初几年中，人脑的广泛而迅速的发展使婴儿期脑水肿的事后诊断变得复杂。这项研究的目的是描述大脑含水量，大脑重量/体重比，以及生命最初几年的大脑重量/头围比率。此外，我们检测了AQP4基因中这些参数与rs2075575之间的关系。我们的假设是水稳态失调可能是婴儿猝死综合征（SIDS）的危险因素，这可能反映在大脑中含水量的增加。该研究包括90例猝死<4岁的受试者：22例婴儿猝死综合征，11例儿童不明原因猝死，因疾病死亡47例，和10例事故/暴力死亡。脑含水量,大脑重量/体重比，根据校正年龄调查大脑重量/头围比率，诊断组,试图复苏，和脑水肿的存在。我们发现脑含水量和脑重量/体重比随着年龄的增长而显著降低,而脑重量/头围增加。脑重量/头围与脑含水量相关。脑水肿病例的脑重量/头围明显高于非水肿病例。对于任何研究参数，诊断组之间均未发现差异。总之,这些发现有助于了解生命最初几个月的大脑发育情况。
