Abstract：
OBJECTIVE: To evaluate the agreement between swept-source OCT (CASIA2) and UBM in primary angle-closure glaucoma.
METHODS: Eighty eyes of 40 participants diagnosed with primary angle-closure glaucoma were examined. Parameters measured included angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), lens vault (LV), anterior chamber depth (ACD), and anterior chamber width (ACW). Angle images of nasal, temporal, superior, and inferior were acquired by the anterior segment mode of CASIA2 and UBM. One-way analysis of variance and paired t-test were used for statistical analysis, and the agreement was analyzed by internal correlation coefficient (ICC) and Bland-Altman method.
RESULTS: One-way ANOVA pairwise comparison showed that CASIA2 or UBM had the narrowest superior chamber angle and the widest temporal chamber angle in patients with primary angle-closure glaucoma. The paired t-test showed that inter-device AOD, TIA, ARA, and TISA of superior chamber angle had significant differences (p < 0.001). There was no significant difference in the measured values of LV, ACD, and ACW (p > 0.05). The agreement of all parameters is good through the Bland-Altman method comparison. ICC result showed moderate agreement in other angle parameters except for superior ARA500 (0.739).
CONCLUSIONS: In the anterior chamber angle measurement process, we should pay more attention to the superior chamber angle covered by eyelids. Although the agreement is acceptable between CASIA2 and UBM, the measurements could not be considered interchangeable due to the tremendous statistical difference between the two devices.
METHODS: Eighty eyes of 40 participants diagnosed with primary angle-closure glaucoma were examined. Parameters measured included angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), lens vault (LV), anterior chamber depth (ACD), and anterior chamber width (ACW). Angle images of nasal, temporal, superior, and inferior were acquired by the anterior segment mode of CASIA2 and UBM. One-way analysis of variance and paired t-test were used for statistical analysis, and the agreement was analyzed by internal correlation coefficient (ICC) and Bland-Altman method.
RESULTS: One-way ANOVA pairwise comparison showed that CASIA2 or UBM had the narrowest superior chamber angle and the widest temporal chamber angle in patients with primary angle-closure glaucoma. The paired t-test showed that inter-device AOD, TIA, ARA, and TISA of superior chamber angle had significant differences (p < 0.001). There was no significant difference in the measured values of LV, ACD, and ACW (p > 0.05). The agreement of all parameters is good through the Bland-Altman method comparison. ICC result showed moderate agreement in other angle parameters except for superior ARA500 (0.739).
CONCLUSIONS: In the anterior chamber angle measurement process, we should pay more attention to the superior chamber angle covered by eyelids. Although the agreement is acceptable between CASIA2 and UBM, the measurements could not be considered interchangeable due to the tremendous statistical difference between the two devices.
摘要：
目的：评估扫频源OCT（CASIA2）与UBM在原发性闭角型青光眼中的一致性。
方法：对被诊断为原发性闭角型青光眼的40名参与者的80只眼进行检查。参数测量夹角开口距离(AOD),角槽区域(ARA),小梁虹膜空间面积（TISA），小梁虹膜角度（TIA），镜头拱顶（LV），前房深度（ACD），和前房宽度（ACW）。鼻腔的角度图像，temporal,上级,下段通过CASIA2和UBM的前节模式获得。采用单因素方差分析和配对t检验进行统计学分析。并通过内部相关系数(ICC)和Bland-Altman方法进行了一致性分析。
结果：单因素方差分析成对比较显示，在原发性闭角型青光眼患者中，CASIA2或UBM具有最窄的上房角和最宽的颞房角。配对t检验表明，器件间AOD，TIA,ARA,上腔角度和TISA差异有统计学意义(p<0.001)。LV的测量值无显著差异，ACD,和ACW(p>0.05)。通过Bland-Altman方法比较，所有参数的一致性很好。ICC结果显示，除优于ARA500（0.739）外，其他角度参数的一致性中等。
结论：在前房角测量过程中，我们应该多注意眼睑覆盖的上腔角度。尽管CASIA2和UBM之间的协议是可以接受的，由于两种设备之间的巨大统计差异，测量结果不能被认为是可互换的。
方法：对被诊断为原发性闭角型青光眼的40名参与者的80只眼进行检查。参数测量夹角开口距离(AOD),角槽区域(ARA),小梁虹膜空间面积（TISA），小梁虹膜角度（TIA），镜头拱顶（LV），前房深度（ACD），和前房宽度（ACW）。鼻腔的角度图像，temporal,上级,下段通过CASIA2和UBM的前节模式获得。采用单因素方差分析和配对t检验进行统计学分析。并通过内部相关系数(ICC)和Bland-Altman方法进行了一致性分析。
结果：单因素方差分析成对比较显示，在原发性闭角型青光眼患者中，CASIA2或UBM具有最窄的上房角和最宽的颞房角。配对t检验表明，器件间AOD，TIA,ARA,上腔角度和TISA差异有统计学意义(p<0.001)。LV的测量值无显著差异，ACD,和ACW(p>0.05)。通过Bland-Altman方法比较，所有参数的一致性很好。ICC结果显示，除优于ARA500（0.739）外，其他角度参数的一致性中等。
结论：在前房角测量过程中，我们应该多注意眼睑覆盖的上腔角度。尽管CASIA2和UBM之间的协议是可以接受的，由于两种设备之间的巨大统计差异，测量结果不能被认为是可互换的。
