OBJECTIVE: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.
METHODS: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.
RESULTS: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.
CONCLUSIONS: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.
目的:本研究的目的是探讨SEMA3C对全身和肾脏血流动力学的影响。
方法:在两个月大的野生型小鼠中静脉注射SEMA3C重组蛋白,以及平均动脉压的变化,心率,肾血流量,和肾血管阻力进行测量和分析。
结果:急性服用SEMA3C诱导(i)全身血流动力学变化,包括平均动脉压降低和心率增加;(ii)肾脏血流动力学变化,包括血管阻力降低和肾血流量升高。连续灌注SEMA3C对全身或肾脏血流动力学无明显影响。
结论:SEMA3C是一种有效的血管扩张剂,可影响小鼠的全身和肾脏血流动力学。