PDF(Pubmed)
Abstract：
BACKGROUND: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown.
OBJECTIVE: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.
METHODS: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.
RESULTS: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.
CONCLUSIONS: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.
OBJECTIVE: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.
METHODS: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.
RESULTS: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.
CONCLUSIONS: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.
摘要：
背景：肾脏血流动力学的改变在肾脏稳态和肾脏疾病中起着至关重要的作用。最近的数据表明，信号蛋白3C(SEMA3C)，一种参与血管发育的分泌糖蛋白，可以调节急性肾损伤的肾血管通透性，但它是否以及如何影响全身和肾脏血流动力学尚不清楚。
目的：本研究的目的是探讨SEMA3C对全身和肾脏血流动力学的影响。
方法：在两个月大的野生型小鼠中静脉注射SEMA3C重组蛋白，以及平均动脉压的变化，心率,肾血流量,和肾血管阻力进行测量和分析。
结果：急性服用SEMA3C诱导（i）全身血流动力学变化，包括平均动脉压降低和心率增加；（ii）肾脏血流动力学变化，包括血管阻力降低和肾血流量升高。连续灌注SEMA3C对全身或肾脏血流动力学无明显影响。
结论：SEMA3C是一种有效的血管扩张剂，可影响小鼠的全身和肾脏血流动力学。
目的：本研究的目的是探讨SEMA3C对全身和肾脏血流动力学的影响。
方法：在两个月大的野生型小鼠中静脉注射SEMA3C重组蛋白，以及平均动脉压的变化，心率,肾血流量,和肾血管阻力进行测量和分析。
结果：急性服用SEMA3C诱导（i）全身血流动力学变化，包括平均动脉压降低和心率增加；（ii）肾脏血流动力学变化，包括血管阻力降低和肾血流量升高。连续灌注SEMA3C对全身或肾脏血流动力学无明显影响。
结论：SEMA3C是一种有效的血管扩张剂，可影响小鼠的全身和肾脏血流动力学。
