%0 News
%T A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics.
%A Cai A
%A Placier S
%A Louedec L
%A Frère P
%A Ouchelouche S
%A Chatziantoniou C
%A Calmont A
%J Nephron
%V 147
%N 7
%D Dec 2023 29
%M 36580904
%F 3.457
%R 10.1159/000528259
%X BACKGROUND: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown.
OBJECTIVE: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.
METHODS: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.
RESULTS: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.
CONCLUSIONS: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.