{Reference Type}: News
{Title}: A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics.
{Author}: Cai A;Placier S;Louedec L;Frère P;Ouchelouche S;Chatziantoniou C;Calmont A;
{Journal}: Nephron
{Volume}: 147
{Issue}: 7
{Year}: Dec 2023 29
{Factor}: 3.457
{DOI}: 10.1159/000528259
{Abstract}: <B>BACKGROUND: </B>Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown.<BR><B>OBJECTIVE: </B>The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.<BR><B>METHODS: </B>SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.<BR><B>RESULTS: </B>Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.<BR><B>CONCLUSIONS: </B>SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.