雷公藤红素和钩藤碱在体外缓解模拟肌肉萎缩中的作用。
关键词: Akt1, serine/threonine-protein kinase or AKT kinase 1 CLS, celastrol Celastrol DEX, dexamethasone DOX, doxorubicin ERK1/2, extracellular signal-regulated kinase 1/2 HSF1, Heat shock factor 1 HSP, heat shock protein ICC, immunocytochemistry MA, Muscular atrophy MAFbx, Muscle Atrophy F-box gene MMP, mitochondrial membrane potential MTCO1, Mitochondrially Encoded Cytochrome C Oxidase I MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MuRF1, Muscle RING Finger protein-1 Muscle atrophy NLS, nuclear localization signals RA, rheumatoid arthritis Rhynchophylline Ryn, Rhynchophylline SMA, spinal muscular atrophy Skeletal muscles VDAC, voltage-dependent anion channel mPTP, mitochondrial permeability transition pore
来 源:
DOI:10.1016/j.jsps.2022.06.008
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