Abstract：
OBJECTIVE: To evaluate the clinical performance of self-assembling peptides versus fluoride-based delivery systems in post-orthodontic white spot lesions.
METHODS: The participants were randomly assigned into two groups (n = 58) according to the remineralizing agent used, where (A) group represented participants receiving a varnish containing 22.600 fluoride ppm and tricalcium phosphate, while the second group (B) represented participants receiving self-assembling peptide. The remineralizing process of the white spot lesion was assessed using the DIAGNOdent pen and ICDAS scoring system according to the time when the remineralizing agent was used (T), where T0 represented the score taken at baseline. T1 represented the score taken after 3 months of follow-ups and T2 score represented the score taken after 6 months of follow-up. Data were collected and statistically analyzed. The parametric data: two-way ANOVA was used to test the effect of interaction among different variables. The non-parametric data: Mann-Whitney test was used. The significance level was set at p ≤ 0.05.
RESULTS: There was a quantitative statistically significant difference via DIAGNOpen readings between Group A (fluoride material) and Group B (self-assembling peptides). The highest mean value of 10.51 was found in Group A, while the least mean value of 6.45 was found in Group B. Besides, there was a significant difference in each group concerning the time factors T0, T1, and T2 groups where (p < 0.001. As for the qualitative results concerning the ICDAS score, there was no significant difference between the two groups along with the follow-up periods T0, T1, and T2 where the p value is equal to 0.064, 0.087, and 0.277 respectively.
CONCLUSIONS: The visual assessment using ICDAS reveals that the biomimetic remineralization using self-assembling peptides and the fluoride-based varnish material showed a similar effect in masking post-orthodontic white spot lesions. However, the laser fluorescence using DIAGNOpen showed that the self-assembling peptides reveal higher performance in subsurface remineralization than the fluoride-based varnish material. Therefore, self-assembling peptides are considered a promising material for lesion regression in post-orthodontics white spot lesions.
CONCLUSIONS: Self-assembling peptide SAP-14 is a new approach to reverse and mask off post-orthodontics white spot lesions.
METHODS: The participants were randomly assigned into two groups (n = 58) according to the remineralizing agent used, where (A) group represented participants receiving a varnish containing 22.600 fluoride ppm and tricalcium phosphate, while the second group (B) represented participants receiving self-assembling peptide. The remineralizing process of the white spot lesion was assessed using the DIAGNOdent pen and ICDAS scoring system according to the time when the remineralizing agent was used (T), where T0 represented the score taken at baseline. T1 represented the score taken after 3 months of follow-ups and T2 score represented the score taken after 6 months of follow-up. Data were collected and statistically analyzed. The parametric data: two-way ANOVA was used to test the effect of interaction among different variables. The non-parametric data: Mann-Whitney test was used. The significance level was set at p ≤ 0.05.
RESULTS: There was a quantitative statistically significant difference via DIAGNOpen readings between Group A (fluoride material) and Group B (self-assembling peptides). The highest mean value of 10.51 was found in Group A, while the least mean value of 6.45 was found in Group B. Besides, there was a significant difference in each group concerning the time factors T0, T1, and T2 groups where (p < 0.001. As for the qualitative results concerning the ICDAS score, there was no significant difference between the two groups along with the follow-up periods T0, T1, and T2 where the p value is equal to 0.064, 0.087, and 0.277 respectively.
CONCLUSIONS: The visual assessment using ICDAS reveals that the biomimetic remineralization using self-assembling peptides and the fluoride-based varnish material showed a similar effect in masking post-orthodontic white spot lesions. However, the laser fluorescence using DIAGNOpen showed that the self-assembling peptides reveal higher performance in subsurface remineralization than the fluoride-based varnish material. Therefore, self-assembling peptides are considered a promising material for lesion regression in post-orthodontics white spot lesions.
CONCLUSIONS: Self-assembling peptide SAP-14 is a new approach to reverse and mask off post-orthodontics white spot lesions.
摘要：
目的：评估自组装肽与基于氟化物的递送系统在正畸后白斑病变中的临床表现。
方法：根据使用的再矿化剂，将参与者随机分为两组（n=58），其中（A）组代表参与者接受含有22.600氟化物ppm和磷酸三钙的清漆，而第二组（B）代表接受自组装肽的参与者。根据使用再矿化剂的时间（T），使用DIAGNOdent笔和ICDAS评分系统评估白斑病变的再矿化过程，其中T0代表基线时的得分。T1代表随访3个月后的得分，T2代表随访6个月后的得分。收集数据并进行统计分析。参数数据：双向方差分析用于测试不同变量之间相互作用的影响。非参数数据:使用Mann-Whitney检验。显著性水平设定为p≤0.05。
结果：通过DIAGNOpen读数，A组（氟化物材料）和B组（自组装肽）之间存在定量统计学上的显着差异。A组的平均值最高为10.51,而B组的平均值最小为6.45，此外，各组在时间因素T0、T1和T2组有显著差异(p<0.001。关于ICDAS评分的定性结果，两组的随访时间T0,T1和T2之间无显著差异,p值分别为0.064,0.087和0.277.
结论：使用ICDAS的视觉评估表明，使用自组装肽和基于氟化物的清漆材料的仿生再矿化在掩盖正畸后白斑病变方面显示出相似的效果。然而,使用DIAGNOpen的激光荧光表明，自组装肽在表面下再矿化方面比基于氟化物的清漆材料表现出更高的性能。因此,自组装肽被认为是正畸后白斑病变消退的有希望的材料。
结论：自组装肽SAP-14是逆转和掩盖正畸后白斑病变的新方法。
方法：根据使用的再矿化剂，将参与者随机分为两组（n=58），其中（A）组代表参与者接受含有22.600氟化物ppm和磷酸三钙的清漆，而第二组（B）代表接受自组装肽的参与者。根据使用再矿化剂的时间（T），使用DIAGNOdent笔和ICDAS评分系统评估白斑病变的再矿化过程，其中T0代表基线时的得分。T1代表随访3个月后的得分，T2代表随访6个月后的得分。收集数据并进行统计分析。参数数据：双向方差分析用于测试不同变量之间相互作用的影响。非参数数据:使用Mann-Whitney检验。显著性水平设定为p≤0.05。
结果：通过DIAGNOpen读数，A组（氟化物材料）和B组（自组装肽）之间存在定量统计学上的显着差异。A组的平均值最高为10.51,而B组的平均值最小为6.45，此外，各组在时间因素T0、T1和T2组有显著差异(p<0.001。关于ICDAS评分的定性结果，两组的随访时间T0,T1和T2之间无显著差异,p值分别为0.064,0.087和0.277.
结论：使用ICDAS的视觉评估表明，使用自组装肽和基于氟化物的清漆材料的仿生再矿化在掩盖正畸后白斑病变方面显示出相似的效果。然而,使用DIAGNOpen的激光荧光表明，自组装肽在表面下再矿化方面比基于氟化物的清漆材料表现出更高的性能。因此,自组装肽被认为是正畸后白斑病变消退的有希望的材料。
结论：自组装肽SAP-14是逆转和掩盖正畸后白斑病变的新方法。
