关键词： , IFN-γ, reduce interferon-gamma , RAS, renin-angiotensin system ACE2, angiotensin-converting enzyme 2 CI, confidence interval COVID-19 Children DAMPs, damage-associated molecular patterns DCs, dendritic cells HR, Hazard Risk ICU, intensive care unit IL, interleukin IgE, immunoglobulin E Immunity MD, mean difference NK, natural killer OR, odds ratio PAMPs, pathogen-associated molecular patterns PRRs, pattern recognition receptors RCTs, randomized control trials RR, risk ratio SARS-CoV-2 infection TLRs, Toll-like receptors TNF-α, tumor necrosis factor-α Treg cells, CD, regulatory T cellcluster of differentiation VDRs, vitamin D receptors Vitamin D

来  源：   DOI：10.1016/j.phanu.2022.100319   PDF(Pubmed)

Abstract：
UNASSIGNED: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D\'s role in the pathophysiology of COVID-19 disease.
UNASSIGNED: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population.
UNASSIGNED: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.
摘要：
未经批准：维生素D影响免疫系统和炎症反应。已知补充维生素D可降低急性呼吸道感染的风险。在过去的两年里,许多研究人员研究了维生素D在COVID-19疾病病理生理中的作用。
UNASSIGNED：从临床试验和系统评价中获得的发现强调，大多数COVID-19患者的维生素D水平降低，维生素D水平低增加了严重疾病的风险。这一证据似乎也在儿科人群中得到证实。
UNASSIGNED：需要对儿童进行进一步的研究（系统评价和荟萃分析），以确认维生素D会影响COVID-19的结局，并确定补充剂的有效性和适当的剂量，持续时间和给药方式。
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