Abstract：
UNASSIGNED: For a long time, natural compounds have been used to accelerate wound healing. In this study, the topical effects of ammoniacum gum extract on wound healing were investigated in white male rats.
UNASSIGNED: Following skin wound induction in aseptic conditions, 48 Wistar rats were divided into six equal groups; phenytoin cream 1% (standard), untreated (control), Eucerin (control), and 5%, 10% and 20% ointments of Dorema ammoniacum gum extract (treatment groups). All experimental groups received topical drugs daily for 14 days. The percentage of wound healing, hydroxyproline content, histological parameters, and growth factors (endothelial growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-α) were measured in experimental groups.
UNASSIGNED: The areas of the wounds in the treatment groups were significantly decreased compared with the wound areas of control groups at 5, 7 and 10 days after wounding. On the 12th day, the wounds in the treatment groups were completely healed. Hydroxyproline contents were significantly increased in the treatment groups compared with the control groups (p<0.001). In histological evaluation, the re-epithelialisation, increasing thickness of the epithelial layer, granulation tissue and neovascularisation parameters in the treatment groups showed significant increases compared with the control groups. Also, serum levels of TGF-β, PDGF, EGF and VEGF in the treatment groups were significantly increased compared to the control groups.
UNASSIGNED: The topical application of ammoniacum gum extract significantly increases the percentage of wound healing in rats and reduces the time of wound closure.
UNASSIGNED: Following skin wound induction in aseptic conditions, 48 Wistar rats were divided into six equal groups; phenytoin cream 1% (standard), untreated (control), Eucerin (control), and 5%, 10% and 20% ointments of Dorema ammoniacum gum extract (treatment groups). All experimental groups received topical drugs daily for 14 days. The percentage of wound healing, hydroxyproline content, histological parameters, and growth factors (endothelial growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-α) were measured in experimental groups.
UNASSIGNED: The areas of the wounds in the treatment groups were significantly decreased compared with the wound areas of control groups at 5, 7 and 10 days after wounding. On the 12th day, the wounds in the treatment groups were completely healed. Hydroxyproline contents were significantly increased in the treatment groups compared with the control groups (p<0.001). In histological evaluation, the re-epithelialisation, increasing thickness of the epithelial layer, granulation tissue and neovascularisation parameters in the treatment groups showed significant increases compared with the control groups. Also, serum levels of TGF-β, PDGF, EGF and VEGF in the treatment groups were significantly increased compared to the control groups.
UNASSIGNED: The topical application of ammoniacum gum extract significantly increases the percentage of wound healing in rats and reduces the time of wound closure.
摘要：
UNASSIGNED：很长一段时间，天然化合物已被用于加速伤口愈合。在这项研究中,在雄性白鼠中研究了氨水胶提取物对伤口愈合的局部作用。
未经证实：在无菌条件下诱导皮肤创伤后，48只Wistar大鼠分为6组；苯妥英乳膏1％（标准），未经治疗（对照），Eucerin（对照），5%,10％和20％的Dorema氨水胶提取物软膏（治疗组）。所有实验组每天接受局部药物治疗，持续14天。伤口愈合的百分比，羟脯氨酸含量,组织学参数，和生长因子(内皮生长因子(EGF)，血小板衍生生长因子(PDGF),在实验组中测量血管内皮生长因子（VEGF）和转化生长因子（TGF）-α。
UNASSIGNED：在受伤后5、7和10天，治疗组的伤口面积与对照组的伤口面积相比明显减少。第12天,治疗组伤口完全愈合。与对照组相比，治疗组的羟脯氨酸含量显着增加（p<0.001）。在组织学评估中，重新上皮化，增加上皮层的厚度，与对照组相比,治疗组肉芽组织和新生血管参数显著增加.此外，血清TGF-β水平，PDGF,与对照组相比,治疗组中的EGF和VEGF显著增加。
UNASSIGNED：局部应用氨水胶提取物可显着增加大鼠伤口愈合的百分比，并减少伤口闭合的时间。
未经证实：在无菌条件下诱导皮肤创伤后，48只Wistar大鼠分为6组；苯妥英乳膏1％（标准），未经治疗（对照），Eucerin（对照），5%,10％和20％的Dorema氨水胶提取物软膏（治疗组）。所有实验组每天接受局部药物治疗，持续14天。伤口愈合的百分比，羟脯氨酸含量,组织学参数，和生长因子(内皮生长因子(EGF)，血小板衍生生长因子(PDGF),在实验组中测量血管内皮生长因子（VEGF）和转化生长因子（TGF）-α。
UNASSIGNED：在受伤后5、7和10天，治疗组的伤口面积与对照组的伤口面积相比明显减少。第12天,治疗组伤口完全愈合。与对照组相比，治疗组的羟脯氨酸含量显着增加（p<0.001）。在组织学评估中，重新上皮化，增加上皮层的厚度，与对照组相比,治疗组肉芽组织和新生血管参数显著增加.此外，血清TGF-β水平，PDGF,与对照组相比,治疗组中的EGF和VEGF显著增加。
UNASSIGNED：局部应用氨水胶提取物可显着增加大鼠伤口愈合的百分比，并减少伤口闭合的时间。
