PDF(Pubmed)
Abstract：
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent, potential metabolic disruptors of concern for infants. Mothers participating in the New Hampshire Birth Cohort Study (NHBCS) provided a plasma sample during pregnancy to measure concentrations of seven PFAS, and infant weight and length were abstracted from well-child visits between birth and 12 months. Sex-specific growth patterns of child body mass index (BMI) were fit using a growth mixture model (GMM) and the relative risk ratios (RRR) and 95% Confidence Intervals (95% CI) for the association of maternal plasma PFAS with BMI growth patterns during infancy were estimated by using multinomial logistic model for the group probabilities in the GMM. Four growth patterns were identified: Group 1) a steep increase in BMI during the first 6 months, then a leveling off; Group 2) a gradual increase in BMI across the year; Group 3) a steep increase in BMI during months 1-3, then stable BMI; and Group 4) a gradual increase in BMI with plateau around 3 months (reference group). For boys, higher maternal pregnancy perfluorooctanoate concentrations were associated with a 60% decreased chance of being in group 3 as compared to group 4, after adjusting for potential confounding variables (RRR = 0.4; 95% CI: 0.1, 0.9). For girls, higher maternal perfluorooctane sulfonate (PFOS) concentrations during pregnancy were associated with a higher likelihood of following the growth pattern of groups 2 (RRR = 2.5; 95% CI: 1.0, 6.1) and 3 (RRR = 2.8; 95% CI: 1.0, 7.6) as compared to group 4, adjusting for potential confounding variables. In this cohort, sex-specific associations of maternal plasma PFAS concentrations during pregnancy with growth patterns during the first year of life were observed, with greater BMI growth observed among infant girls born to mothers with higher pregnancy concentrations of PFOS.
摘要：
全氟烷基和多氟烷基物质（PFAS）对环境具有持久性，潜在的代谢干扰物关注的婴儿。参加新罕布什尔州出生队列研究（NHBCS）的母亲在怀孕期间提供了血浆样本，以测量七种PFAS的浓度。婴儿体重和身长是从出生至12个月之间的良好子女访视中提取的。使用生长混合模型（GMM）拟合儿童体重指数（BMI）的性别特定生长模式，并使用相对风险比（RRR）和95％置信区间（95％CI）将母体血浆PFAS与BMI相关联婴儿期的增长模式通过使用多项逻辑逻辑模型估算GMM中的组概率。确定了四种增长模式：第1组）前6个月BMI急剧增加，然后趋于平稳；第2组）BMI全年逐渐增加；第3组）在第1-3个月内BMI急剧增加，然后BMI稳定；第4组）BMI逐渐增加，并在3个月左右达到平稳状态（参照组）。对于男孩来说，在校正潜在混杂变量后,与第4组相比,第3组孕妇妊娠全氟辛酸盐浓度较高的发生率降低了60%(RRR=0.4;95%CI:0.1,0.9).对于女孩来说,与第4组相比,妊娠期母体全氟辛烷磺酸(PFOS)浓度较高与第2组(RRR=2.5;95%CI:1.0,6.1)和第3组(RRR=2.8;95%CI:1.0,7.6)遵循生长模式的可能性较高相关,校正了潜在的混杂变量.在这个队列中，观察到怀孕期间母体血浆PFAS浓度与出生后第一年生长模式的性别特异性关联,在妊娠全氟辛烷磺酸浓度较高的母亲所生的女婴中观察到更大的BMI增长。
