■全氟烷基物质(PFAS)由于其有用的特性而广泛用于工业和日常生活中。它们的半衰期很长,积聚在体内,有证据表明它们与脂质代谢和肝损伤的生物标志物有关。这可能提示由PFAS引起的非酒精性脂肪性肝病(NAFLD)。然而,因为没有研究分析韩国整个人群中PFAS和NAFLD之间的关系。我们试图使用韩国国家环境健康调查(KoNEHS)第4周期来确认韩国成年人血清PFAS浓度与NAFLD患病率之间的关系。
■该研究于2018-2019年在KoNEHS参与者中对2,529名受试者进行。对于NAFLD的诊断,使用肝脏脂肪变性指数(HSI),并给出了血清PFAS的几何平均值和浓度分布。进行Logistic回归以确认由于PFAS浓度的变化而导致的NAFLD风险增加。并计算比值比和95%置信区间(CI)。
■在调整和未调整的型号中,在非肥胖组中,随着血清总PFAS和全氟辛烷磺酸(PFOS)浓度的增加,比值比也增加.在调整后的模型中,血清总PFAS和PFOS的比值比分别为6.401(95%CI:1.883~21.758)和7.018(95%CI:2.688~18.319).
■在这项研究中,基于HSI的NAFLD的高风险与血清总PFAS相关,非肥胖组的全氟辛烷磺酸。基于放射学或组织学证据的NAFLD诊断和长期前瞻性研究的进一步研究是必要的。因此,在工业和日常生活中,有必要找到减少PFAS接触的方法。
UNASSIGNED: Perfluoroalkyl substances (PFAS) are widely used in industry and daily life due to their useful properties. They have a long half-life, accumulate in the body, and there is evidence that they are associated with biomarkers of lipid metabolism and liver damage. This may suggest non-alcoholic fatty liver disease (NAFLD) caused by PFAS. However, since there has been no study analyzing the relationship between PFAS and NAFLD in the entire population in Korea. We sought to confirm the relationship between serum PFAS concentration and NAFLD prevalence in Korean adults using the Korean National Environmental Health Survey (KoNEHS) cycle 4.
UNASSIGNED: The study was conducted on 2,529 subjects in 2018-2019 among KoNEHS participants. For the diagnosis of NAFLD, the hepatic steatosis index (HSI) was used, and the geometric mean and concentration distribution of serum PFAS were presented. Logistic regression was performed to confirm the increase in the risk of NAFLD due to changes in PFAS concentration, and the odds ratio and 95% confidence interval (CI) were calculated.
UNASSIGNED: In both adjusted and unadjusted models, an increased odds ratio was observed with increasing serum concentrations of total PFAS and perfluorooctane sulfonate (PFOS) in the non-obese group. In the adjusted model, the odds ratios for serum total PFAS and PFOS were 6.401 (95% CI: 1.883-21.758) and 7.018 (95% CI: 2.688-18.319).
UNASSIGNED: In this study, a higher risk of NAFLD based on HSI was associated with serum total PFAS, PFOS in non-obese group. Further research based on radiological or histological evidence for NAFLD diagnosis and long-term prospective studies are necessary. Accordingly, it is necessary to find ways to reduce exposure to PFAS in industry and daily life.