组织蛋白酶 V 的新抑制剂损害肿瘤细胞增殖和弹性蛋白降解并增加免疫细胞的细胞毒性。
关键词: 7-AAD, 7-aminoactinomycin D ATCC, American Type Culture Collection AUC, area under curve Antitumor therapy CFSE, carboxyfluorescein succinimidyl ester CTLs, cytotoxic T lymphocytes Cancer Cathepsin V Cystatin F DMEM, Dulbecco’s modified Eagle’s medium E2F1, E2 promoter-binding factor 1 E:T, effector-to-target ratio FBS, fetal bovine serum LHVS, morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl MDCK, Madin−Darby Canine Kidney cells MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymetoxyphenyl)-2-(4-sulfophenyl)–2H-tetrazolium NK, natural killer PMA, phorbol 12-myristate 13-acetate RMSD, Root Mean Square Deviation Small-Molecule Inhibitors
来 源:
DOI:10.1016/j.csbj.2022.08.046
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