分子研究已经确定了各种治疗相关的预后分子,以增强结直肠癌(CRC)治疗的有效性并提高生存率。组织蛋白酶V在胃肠道癌细胞中的表达促使人们研究其作为CRC预后指标的潜力。组织蛋白酶V的表达及其临床病理意义的评估通过组织芯片中的免疫组织化学进行。包括142个CRC和正常结直肠组织。总体和无病生存率,基于组织蛋白酶V的表达水平,使用Kaplan-Meier方法进行评估,并使用对数秩检验进行比较。单变量和多变量分析,采用Cox比例风险模型,进行以确定预后因素。组织蛋白酶V的表达与年龄无关,性别,肿瘤位置,肿瘤大小,或组织学分级。然而,与肿瘤浸润深度显著相关,区域淋巴结(LN)转移,远处转移,和淋巴血管受累(均p<0.001)。低组织蛋白酶V表达的总生存率和无病生存率显著优于高表达(p<0.001)。单因素分析确定了几个预后因素,包括组织学分级(低与高),肿瘤大小(≤vs.>5cm),肿瘤深度(T1vs.≥T2),区域LN转移,远处转移,肿瘤淋巴结转移(TNM)分期(I期vs≥II期),淋巴血管受累,和组织蛋白酶V的表达。多因素分析显示,肿瘤深度,远处转移,和组织蛋白酶V的表达是生存不良的独立预测因子。组织蛋白酶V在CRC中经常表达,高表达与预后不良有关。因此,组织蛋白酶V是一种有用的CRC预后标志物.
Molecular studies have identified various treatment-related prognostic molecules to enhance the effectiveness of colorectal cancer (CRC) treatment and improve survival rates. The expression of cathepsin V in gastrointestinal cancer cells prompted an investigation into its potential as a prognostic indicator for CRC. The evaluation of cathepsin V expression and its clinicopathological significance was conducted through immunohistochemistry in a tissue microarray, encompassing 142 CRC and normal colorectal tissues. Overall and disease-free survival rates, based on cathepsin V expression levels, were assessed using the Kaplan-Meier method and compared utilizing the log-rank test. Univariate and multivariate analyses, employing a Cox proportional hazards model, were performed to identify prognostic factors. Cathepsin V expression exhibited no correlation with age, sex, tumor location, tumor size, or histological grade. However, it was significantly correlated with depth of tumor invasion, regional lymph node (LN) metastasis, distant metastasis, and lymphovascular involvement (all p<0.001). Overall and disease-free survival rates were significantly better with low cathepsin V expression than with high expression (p<0.001). Univariate analysis identified several prognostic factors, including histological grade (low vs. high), tumor size (≤ vs. >5 cm), tumor depth (T1 vs. ≥T2), regional LN metastasis, distant metastasis, tumor-node-metastasis (TNM) stage (Stage I vs ≥II), lymphovascular involvement, and cathepsin V expression. Multivariate analysis revealed that tumor depth, distant metastasis, and cathepsin V expression are independent predictors of poor survival. Cathepsin V is frequently expressed in CRC, and its high expression is associated with poor prognosis. Therefore, cathepsin V is a useful prognostic marker for CRC.