Abstract：
Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks’ gestation, BMI ≥ 29 kg/m2. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24−28 and 35−37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0.34, p = 0.012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.
摘要：
维生素D缺乏是超重/肥胖孕妇的常见发现，并与不良妊娠结局的风险增加有关。母体维生素D缺乏和母体肥胖都会导致妊娠期代谢紊乱。我们旨在评估妊娠期补充维生素D3与安慰剂对母体和胎儿血脂的影响。主要纳入标准为：女性妊娠20周，BMI≥29kg/m2。符合条件的女性（n=154）随机接受维生素D3（1600IU/天）或安慰剂。在出生时进行评估<20、24-28和35-37周。使用线性回归模型评估维生素D对母体和脐带血脂的影响。在维生素D组中，与安慰剂相比，母体和脐带血中的总25-OHD和25-OHD3水平明显更高。调整后的回归模型没有显示甘油三酯的任何差异，LDL-C,HDL-C,游离脂肪酸,组间酮体或瘦素。两组新生儿的皮褶总和相当，但与脐带血25-OH-D3呈正相关(r=0.34,p=0.012)。怀孕期间补充维生素D会显著增加母体和脐带血维生素D，从而导致维生素D充足率较高。母亲和脐带血的血脂参数不受维生素D3补充的影响。
